WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406416
CAS#: 450839-40-4 (free base)
Description: ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally).
MedKoo Cat#: 406416
Name: ABT-100
CAS#: 450839-40-4 (free base)
Chemical Formula: C27H19F3N4O3
Exact Mass: 504.14093
Molecular Weight: 504.46
Elemental Analysis: C, 64.28; H, 3.80; F, 11.30; N, 11.11; O, 9.51
Related CAS #: 450839-40-4 (free base) 852926-14-8 (HCl)
Synonym: ABT100; ABT 100; ABT-100; A367074; A 367074; A-367074
IUPAC/Chemical Name: (S)-6-(2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy)-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbonitrile
InChi Key: HEUVRFNVTLGKMZ-SANMLTNESA-N
InChi Code: InChI=1S/C27H19F3N4O3/c1-34-17-33-15-25(34)26(35,21-7-2-18(13-31)3-8-21)16-36-24-11-4-19(14-32)12-23(24)20-5-9-22(10-6-20)37-27(28,29)30/h2-12,15,17,35H,16H2,1H3/t26-/m0/s1
SMILES Code: N#CC1=CC(C2=CC=C(OC(F)(F)F)C=C2)=C(OC[C@](O)(C3=CC=C(C#N)C=C3)C4=CN=CN4C)C=C1
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