WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 401012
Description: A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively.
MedKoo Cat#: 401012
Chemical Formula: C22H22N4O
Exact Mass: 358.17936
Molecular Weight: 358.43628
Elemental Analysis: C, 73.72; H, 6.19; N, 15.63; O, 4.46
A-674563, purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 70 days after order is received.
Synonym: A674563; A 674563; A-674563
IUPAC/Chemical Name: (S)-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine
InChi Key: BPNUQXPIQBZCMR-IBGZPJMESA-N
InChi Code: InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1
SMILES Code: N[C@@H](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(NN=C4C)C=C3)=CN=C2
The following data is based on the product molecular weight 358.43628 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Tei H, Miyake H, Fujisawa M. Enhanced sensitivity to sorafenib by inhibition
of Akt1 expression in human renal cell carcinoma ACHN cells both in vitro and in
vivo. Hum Cell. 2015 Apr 11. [Epub ahead of print] PubMed PMID: 25862630.