A-674563
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 401012

CAS#: 552325-73-2

Description: A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively.


Chemical Structure

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A-674563
CAS# 552325-73-2

Theoretical Analysis

MedKoo Cat#: 401012
Name: A-674563
CAS#: 552325-73-2
Chemical Formula: C22H22N4O
Exact Mass: 358.17936
Molecular Weight: 358.43628
Elemental Analysis: C, 73.72; H, 6.19; N, 15.63; O, 4.46

Price and Availability

Size Price Availability Quantity
5.0mg USD 485.0 2 Weeks
10.0mg USD 885.0 2 Weeks
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Synonym: A674563; A 674563; A-674563

IUPAC/Chemical Name: (S)-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine

InChi Key: BPNUQXPIQBZCMR-IBGZPJMESA-N

InChi Code: InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1

SMILES Code: N[C@@H](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(NN=C4C)C=C3)=CN=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 358.43628 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 1: Tei H, Miyake H, Fujisawa M. Enhanced sensitivity to sorafenib by inhibition
of Akt1 expression in human renal cell carcinoma ACHN cells both in vitro and in
vivo. Hum Cell. 2015 Apr 11. [Epub ahead of print] PubMed PMID: 25862630.