WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 401010
CAS#: 552325-16-3
Description: A-443654 is a potent and selective AKT inhibitor. A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. A-443654 interferes with mitotic progression by regulating aurora a kinase expression.
MedKoo Cat#: 401010
Name: A-443654
CAS#: 552325-16-3
Chemical Formula: C24H23N5O
Exact Mass: 397.19026
Molecular Weight: 397.47
Elemental Analysis: C, 72.52; H, 5.83; N, 17.62; O, 4.03
Synonym: A443564; A-443564; A 443564.
IUPAC/Chemical Name: (S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine
InChi Key: YWTBGJGMTBHQTM-IBGZPJMESA-N
InChi Code: InChI=1S/C24H23N5O/c1-15-22-10-16(6-7-24(22)29-28-15)17-9-20(13-26-11-17)30-14-19(25)8-18-12-27-23-5-3-2-4-21(18)23/h2-7,9-13,19,27H,8,14,25H2,1H3,(H,28,29)/t19-/m0/s1
SMILES Code: N[C@H](COC1=CC(C2=CC3=C(C)NN=C3C=C2)=CN=C1)CC4=CNC5=C4C=CC=C5
1: Liu X, Shi Y, Woods KW, Hessler P, Kroeger P, Wilsbacher J, Wang J, Wang JY, Li C, Li Q, Rosenberg SH, Giranda VL, Luo Y. Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression. Neoplasia. 2008 Aug;10(8):828-37. PubMed PMID: 18670641; PubMed Central PMCID: PMC2481570.
2: Han EK, Leverson JD, McGonigal T, Shah OJ, Woods KW, Hunter T, Giranda VL, Luo Y. Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. Oncogene. 2007 Aug 16;26(38):5655-61. Epub 2007 Mar 5. PubMed PMID: 17334390.