WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406504
Description: 4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome alignment defects and formation of multi-polar spindles. Furthermore, preliminary data from preclinical studies suggest low propensity towards bone marrow toxicities at concentrations that inhibit tumor growth in paclitaxel-resistant xenograft models. 4SC-207 may be a potential anti-cancer agent.
MedKoo Cat#: 406504
Chemical Formula: C19H18N4O3S
Exact Mass: 382.10996
Molecular Weight: 382.43622
Elemental Analysis: C, 59.67; H, 4.74; N, 14.65; O, 12.55; S, 8.38
4SC-207,purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 70 days after order is received.
Synonym: 4SC207; 4SC-207; 4SC 207
IUPAC/Chemical Name: (E)-ethyl 3-cyano-2-(3-(pyridin-3-yl)acrylamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate.
InChi Key: KNQCFGQPDILWLT-AATRIKPKSA-N
InChi Code: InChI=1S/C19H18N4O3S/c1-2-26-19(25)23-9-7-14-15(10-20)18(27-16(14)12-23)22-17(24)6-5-13-4-3-8-21-11-13/h3-6,8,11H,2,7,9,12H2,1H3,(H,22,24)/b6-5+
SMILES Code: O=C(OCC)N1CCC2=C(SC(NC(/C=C/C3=CC=CN=C3)=O)=C2C#N)C1
The following data is based on the product molecular weight 382.43622 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Bausch E, Kohlhof H, Hamm S, Krauss R, Baumgartner R, Sironi L. A novel microtubule inhibitor 4SC-207 with anti-proliferative activity in taxane-resistant cells. PLoS One. 2013 Nov 6;8(11):e79594. doi: 10.1371/journal.pone.0079594. eCollection 2013. PubMed PMID: 24324550; PubMed Central PMCID: PMC3855670.