TXA127

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205655

CAS#: 51833-78-4

Description: TXA127, also known as Angiotensin i (1-7), is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phophorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 Mapk signaling pathway.


Chemical Structure

img
TXA127
CAS# 51833-78-4

Theoretical Analysis

MedKoo Cat#: 205655
Name: TXA127
CAS#: 51833-78-4
Chemical Formula: C41H62N12O11
Exact Mass: 898.4661
Molecular Weight: 899.02
Elemental Analysis: C, 54.78; H, 6.95; N, 18.70; O, 19.58

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2021-03-01. Prices are subject to change without notice.

TXA127 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: TXA127; TXA 127; TXA127; Angiotensin i (1-7); therapeutic angiotensin(17)

IUPAC/Chemical Name: L-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline

InChi Key: PVHLMTREZMEJCG-GDTLVBQBSA-N

InChi Code: InChI=1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1

SMILES Code: O=C(O)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O)CCC1

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 899.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

 1: Ábrigo J, Simon F, Cabrera D, Cabello-Verrugio C. Angiotensin-(1-7) Prevents
Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β)
via Mas Receptor Activation. Cell Physiol Biochem. 2016 Nov 14;40(1-2):27-38.
[Epub ahead of print] PubMed PMID: 27842312.

2: Magalhães GS, Rodrigues-Machado MD, Motta-Santos D, Alenina N, Bader M, Santos
RA, Barcelos LS, Campagnole-Santos MJ. CHRONIC ALLERGIC PULMONARY INFLAMMATION IS
AGGRAVATED IN ANGIOTENSIN-(1-7) MAS RECEPTOR KNOCKOUT MICE. Am J Physiol Lung
Cell Mol Physiol. 2016 Nov 4:ajplung.00029.2016. doi: 10.1152/ajplung.00029.2016.
[Epub ahead of print] PubMed PMID: 27815255.

3: Yu L, Yuan K, Phuong HT, Park BM, Kim SH. Angiotensin-(1-5), an active
mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor.
Peptides. 2016 Sep 20;86:33-41. doi: 10.1016/j.peptides.2016.09.009. [Epub ahead
of print] PubMed PMID: 27660028.

4: Brosnihan KB, M Pulgar V, Bharadwaj MS, Neves LA, Yamaleyeva LM. Local
intra-uterine Ang-(1-7) infusion attenuates PGE(2) and 6-keto PGF(1α) in
decidualized uterus of pseudopregnant rats. Reprod Biol Endocrinol. 2016 Oct
18;14(1):68. PubMed PMID: 27756404; PubMed Central PMCID: PMC5070151.



Additional Information

In 2010, TXA127 was granted Orphan Drug designation as a treatment to enhance engraftment in patients receiving a stem cell transplant. TXA127 has also received Orphan Drug designation for the treatment of Myelodysplastic Syndrome (MDS).