WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206010
CAS#: 22089-22-1
Description: Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and tumor cell apoptosis.
MedKoo Cat#: 206010
Name: Trofosfamide
CAS#: 22089-22-1
Chemical Formula: C9H18Cl3N2O2P
Exact Mass: 322.01715
Molecular Weight: 323.58418
Elemental Analysis: C, 33.41; H, 5.61; Cl, 32.87; N, 8.66; O, 9.89; P, 9.57
Trofosfamide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: Trofosfamide; Ixoten; Genoxal Trofosfamida; A4828
IUPAC/Chemical Name: 2-(bis(2-chloroethyl)amino)-3-(2-chloroethyl)-1,3,2-oxazaphosphinane 2-oxide
InChi Key: UMKFEPPTGMDVMI-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H18Cl3N2O2P/c10-2-6-13-5-1-9-16-17(13,15)14(7-3-11)8-4-12/h1-9H2
SMILES Code: ClCCN1P(OCCC1)(N(CCCl)CCCl)=O
The following data is based on the product molecular weight 323.58418 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
