Trofosfamide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206010

CAS#: 22089-22-1

Description: Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and tumor cell apoptosis.


Chemical Structure

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Trofosfamide
CAS# 22089-22-1

Theoretical Analysis

MedKoo Cat#: 206010
Name: Trofosfamide
CAS#: 22089-22-1
Chemical Formula: C9H18Cl3N2O2P
Exact Mass: 322.01715
Molecular Weight: 323.58418
Elemental Analysis: C, 33.41; H, 5.61; Cl, 32.87; N, 8.66; O, 9.89; P, 9.57

Price and Availability

Size Price Availability Quantity
50.0mg USD 350.0 2 Weeks
100.0mg USD 650.0 2 Weeks
250.0mg USD 950.0 2 Weeks
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Synonym: Trofosfamide; Ixoten; Genoxal Trofosfamida; A4828

IUPAC/Chemical Name: 2-(bis(2-chloroethyl)amino)-3-(2-chloroethyl)-1,3,2-oxazaphosphinane 2-oxide

InChi Key: UMKFEPPTGMDVMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H18Cl3N2O2P/c10-2-6-13-5-1-9-16-17(13,15)14(7-3-11)8-4-12/h1-9H2

SMILES Code: ClCCN1P(OCCC1)(N(CCCl)CCCl)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 323.58418 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information