Totrombopag

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 202963

CAS#: 376592-42-6 (free base)

Description: Totrombopag, also known as SB559448, LGD-4665; is being developed by GlaxoSmithKline, which a back-up compound for eltrombopag (SB-497115).


Chemical Structure

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Totrombopag
CAS# 376592-42-6 (free base)

Theoretical Analysis

MedKoo Cat#: 202963
Name: Totrombopag
CAS#: 376592-42-6 (free base)
Chemical Formula: C25H22N8O2
Exact Mass: 466.18657
Molecular Weight: 466.49
Elemental Analysis: C, 64.37; H, 4.75; N, 24.02; O, 6.86

Size Price Shipping out time Quantity
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Pricing updated 2021-03-03. Prices are subject to change without notice.

Totrombopag is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Related CAS #: 376592-42-6 (free base)   851606-62-7 (choline)    

Synonym: SB559448; SB 559448; SB-559448; LGD-4665; LGD4665; LGD 4665; GSK2285921; GSK-2285921; GSK 2285921; C116875; Totrombopag.

IUPAC/Chemical Name: (E)-1-(3,4-dimethylphenyl)-4-((2-hydroxy-3'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)diazenyl)-3-methyl-1H-pyrazol-5(4H)-one.

InChi Key: KWJKFQSAMABKBG-CYYJNZCTSA-N

InChi Code: InChI=1S/C25H22N8O2/c1-14-10-11-19(12-15(14)2)33-25(35)22(16(3)30-33)27-26-21-9-5-8-20(23(21)34)17-6-4-7-18(13-17)24-28-31-32-29-24/h4-13,22,34H,1-3H3,(H,28,29,31,32)/b27-26+

SMILES Code: O=C1C(/N=N/C2=C(O)C(C3=CC=CC(C4=NNN=N4)=C3)=CC=C2)C(C)=NN1C5=CC=C(C)C(C)=C5

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 466.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor. Alper, Phil B.; Marsilje, Thomas H.; Mutnick, Daniel; Lu, Wenshuo; Chatterjee, Arnab; Roberts, Michael J.; He, Yun; Karanewsky, Donald S.; Chow, Donald; Lao, Jianmin; Gerken, Andrea; Tuntland, Tove; Liu, Bo; Chang, Jonathan; Gordon, Perry; Seidel, H. Martin; Tian, Shin-Shay. Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA. Bioorganic & Medicinal Chemistry Letters (2008), 18(19), 5255-5258. Publisher: Elsevier Ltd., CODEN: BMCLE8 ISSN: 0960-894X. Journal written in English. CAN 149:548251 AN 2008:1138522 CAPLUS



Additional Information

 Related CAS#
376592-42-6 (Totrombopag)
851606-62-7 (Totrombopag choline)