WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 202960
Description: TL-310 is a new taxane analog that demonstrates potent antitumor activity in a variety of human cancer cell lines and in human tumor xenografts. The mechanism of action of TL-310 includes microtubule polymerization, resulting in a block in the G2/M phase of the cell cycle and programmed cell death (apoptosis). In the 786-0 human renal carcinoma model, oral TL-310 (80 mg/kg) was equally efficacious as IV administered paclitaxel or docetaxel. Orally administered TL-310 consistently maintained excellent antitumor efficacy which was well below its maximum tolerated dose in mice.
MedKoo Cat#: 202960
Chemical Formula: C45H55NO16
Exact Mass: 865.35208
Molecular Weight: 865.91
Elemental Analysis: C, 62.42; H, 6.40; N, 1.62; O, 29.56
This product is not in stock, which may be available by custom synthesis.
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Synonym: TL310; TL310; TL 310.
IUPAC/Chemical Name: 2-Furanpropanoic acid, .alpha.-hydroxy-.beta.-[[(2-methylpropoxy)carbonyl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-6-[(cyclopropylcarbonyl)oxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (.alpha.R,.beta.R)-
SMILES Code: O=C(O[C@@H]1C(C)=C(C2(C)C)[C@@H](OC(C3CC3)=O)C([C@@]([C@@H](O)C4)(C)[C@]([C@@]5(OC(C)=O)[C@]4([H])OC5)([H])[C@H](OC(C6=CC=CC=C6)=O)[C@]2(O)C1)=O)[C@H](O)[C@@H](NC(OCC(C)C)=O)C7=CC=CO7
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 865.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Singh, Chandra Ulagaraj. Solid nanoparticle formulation of water insoluble pharmaceuticals with reduced Ostwald ripening. PCT Int. Appl. (2008), 134pp. CODEN: PIXXD2 WO 2008013785 A2 20080131 CAN 148:198644 AN 2008:124314