WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206078
Description: Teroxirone, also known as Triglycidyl Isocyanurate and Tris(2,3-epoxypropyl) Isocyanurate, is a triazene triepoxide with antineoplastic activity. Teroxine alkylates and cross-links DNA, thereby inhibiting DNA replication.
MedKoo Cat#: 206078
Chemical Formula: C12H15N3O6
Exact Mass: 297.09609
Molecular Weight: 297.26
Elemental Analysis: C, 48.48; H, 5.09; N, 14.14; O, 32.29
Teroxirone, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).
Synonym: Teroxirone; Henkels Compound; alphaTGI; alpha-triglycidyl isocyanurate; Triglycidyl Isocyanurate; Tris(2,3-epoxypropyl) Isocyanurate.
IUPAC/Chemical Name: 1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione
SMILES Code: O=C(N(CC1OC1)C(N2CC3OC3)=O)N(CC4OC4)C2=O
The following data is based on the product molecular weight 297.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wang JP, Lin KH, Liu CY, Yu YC, Wu PT, Chiu CC, Su CL, Chen KM, Fang K. Teroxirone inhibited growth of human non-small cell lung cancer cells by activating p53. Toxicol Appl Pharmacol. 2013 Aug 15;273(1):110-120. doi: 10.1016/j.taap.2013.08.007. [Epub ahead of print] PubMed PMID: 23954467.
2: Rubin J, Kovach JS, Ames MM, Moertel CG, Creagan ET, O'Connell MJ. Phase I study of two schedules of teroxirone. Cancer Treat Rep. 1987 May;71(5):489-92. PubMed PMID: 3567975.
3: Ames MM, Kovach JS, Rubin J. Pharmacological characterization of teroxirone, a triepoxide antitumor agent, in rats, rabbits, and humans. Cancer Res. 1984 Sep;44(9):4151-6. PubMed PMID: 6744326.
4: Neidhart JA, Derocher D, Grever MR, Kraut EH, Malspeis L. Phase I trial of teroxirone. Cancer Treat Rep. 1984 Sep;68(9):1115-9. PubMed PMID: 6478450