WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206078

CAS#: 59653-73-5

Description: Teroxirone, also known as Triglycidyl Isocyanurate and Tris(2,3-epoxypropyl) Isocyanurate, is a triazene triepoxide with antineoplastic activity. Teroxine alkylates and cross-links DNA, thereby inhibiting DNA replication.

Chemical Structure

CAS# 59653-73-5

Theoretical Analysis

MedKoo Cat#: 206078
Name: Teroxirone
CAS#: 59653-73-5
Chemical Formula: C12H15N3O6
Exact Mass: 297.09609
Molecular Weight: 297.26
Elemental Analysis: C, 48.48; H, 5.09; N, 14.14; O, 32.29

Price and Availability

Size Price Availability Quantity
1.0g USD 80.0 2 Weeks
5.0g USD 190.0 2 Weeks
10.0g USD 250.0 2 Weeks
50.0g USD 450.0 2 Weeks
100.0g USD 650.0 2 Weeks
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Synonym: Teroxirone; Henkels Compound; alphaTGI; alpha-triglycidyl isocyanurate; Triglycidyl Isocyanurate; Tris(2,3-epoxypropyl) Isocyanurate.

IUPAC/Chemical Name: 1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 297.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wang JP, Lin KH, Liu CY, Yu YC, Wu PT, Chiu CC, Su CL, Chen KM, Fang K. Teroxirone inhibited growth of human non-small cell lung cancer cells by activating p53. Toxicol Appl Pharmacol. 2013 Aug 15;273(1):110-120. doi: 10.1016/j.taap.2013.08.007. [Epub ahead of print] PubMed PMID: 23954467.

2: Rubin J, Kovach JS, Ames MM, Moertel CG, Creagan ET, O'Connell MJ. Phase I study of two schedules of teroxirone. Cancer Treat Rep. 1987 May;71(5):489-92. PubMed PMID: 3567975.

3: Ames MM, Kovach JS, Rubin J. Pharmacological characterization of teroxirone, a triepoxide antitumor agent, in rats, rabbits, and humans. Cancer Res. 1984 Sep;44(9):4151-6. PubMed PMID: 6744326.

4: Neidhart JA, Derocher D, Grever MR, Kraut EH, Malspeis L. Phase I trial of teroxirone. Cancer Treat Rep. 1984 Sep;68(9):1115-9. PubMed PMID: 6478450

Additional Information

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