WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206205
CAS#: 1308672-74-3
Description: Sulfatinib, also known as surufatinib, is an orally bioavailable, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, and the fibroblast growth factor receptor type 1 (FGFR1), with potential antineoplastic and anti-angiogenic activities. Upon oral administration, sulfatinib binds to and inhibits VEGFRs and FGFR1 thereby inhibiting VEGFR- and FGFR1-mediated signal transduction pathways. This leads to a reduction of angiogenesis and tumor cell proliferation in VEGFR/FGFR1-overexpressing tumor cells. Expression of VEGFRs and FGFR1 may be upregulated in a variety of tumor cell types.
MedKoo Cat#: 206205
Name: Sulfatinib
CAS#: 1308672-74-3
Chemical Formula: C24H28N6O3S
Exact Mass: 480.1944
Molecular Weight: 480.587
Elemental Analysis: C, 59.98; H, 5.87; N, 17.49; O, 9.99; S, 6.67
Sulfatinib, purity > 98%, is in stock. The same day shipping out after order is received.
Related CAS #: 1308672-74-3 1816307-67-1.
Synonym: HMPL012; HMPL012; HMPL 012; Sulfatinib; surufatinib;
IUPAC/Chemical Name: N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide
InChi Key: TTZSNFLLYPYKIL-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29)
SMILES Code: CC1=CC2=C(N1)C=CC(OC3=NC(NC4=CC(CS(NCCN(C)C)(=O)=O)=CC=C4)=NC=C3)=C2
The following data is based on the product molecular weight 480.587 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
