WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 205627
Description: Sonoflora 1, also known as SF1, a PDT photosensitivizer. Chemically, SF1 is an analog of chlorophyll in that its macrocycle backbone is porphyrin-based and the center of the porphyrin ring consists of a metal ion. Preclinical studies showed that SF1 had very high sonodynamic as well as photodynamic activity. The clinically tested results demonstrated positive therapeutic effects for treating patients with advanced refractory breast cancers that had failed to respond to conventional chemotherapy.
MedKoo Cat#: 205627
Name: Sonoflora 1
Chemical Formula: C38H42N6O10Sn
Exact Mass: 862.19844
Molecular Weight: 861.48
Sonoflora 1 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: Sonoflora 1; Sonoflora1; Sonoflora-1; SF1; SF-1; SF 1.
IUPAC/Chemical Name: Stannate(3-), [N-[2-[(7S,8S)-3-carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl-κN21,κN22,κN23,κN24]acetyl]glycylglycinato(5-)]dihydroxy-, sodium (1:3), (OC-6-13)-
InChi Key: YFKGEMWMQNGXOZ-IGVQWUNUSA-G
InChi Code: InChI=1S/C38H42N6O8.3Na.2H2O.Sn/c1-7-21-17(3)25-12-27-19(5)23(9-10-33(47)48)36(43-27)24(11-31(45)39-15-32(46)40-16-34(49)50)37-35(38(51)52)20(6)28(44-37)14-30-22(8-2)18(4)26(42-30)13-29(21)41-25;;;;;;/h7,12-14,19,23H,1,8-11,15-16H2,2-6H3,(H7,39,40,41,42,43,44,45,46,47,48,49,50,51,52);;;;2*1H2;/q;3*+1;;;+4/p-7/t19-,23-;;;;;;/m0....../s1
SMILES Code: O=C(NCC(NCC(O[Na])=O)=O)C/C1=C2[C@@H](CCC(O[Na])=O)[C@H](C)C(/C=C3C(C)=C(C=C)/C4=C/C(C(C)=C/5CC)=NC5=C/C6=C(C)C(C(O[Na])=O)=C1N6[Sn-2]([OH+])([OH+])N4/3)=N\2
The following data is based on the product molecular weight 861.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wang X, Zhang W, Xu Z, Luo Y, Mitchell D, Moss RW. Sonodynamic and photodynamic therapy in advanced breast carcinoma: a report of 3 cases. Integr Cancer Ther. 2009 Sep;8(3):283-7. PubMed PMID: 19815599.
Sonodynamic therapy (SDT) has been developed as a complementary or alternative therapy to PDT. There are data to show that an additive effect might be obtained if SDT is combined with PDT. There are also data showing that PDT is synergistic with chemotherapeutic agents. In SDT treatment, patients first ingest a sonosensitizer, a drug that can be activated by ultrasound. This drug is then activated through the use of low-intensity ultrasound, producing a cascade of endogenous cytotoxic agents. The therapy is thus similar to PDT, except that the sensitizer is activated by ultrasound rather than by light. The body transmits ultrasound much more efficiently than light, and this is a decisive advantage when treating deeper tumors. ( Source: Integr Cancer Ther 8(3) (2009) 283)