SF1 | SF-1 | Sonoflora 1 | CAS#1609250-37-4 | Photodynamic therapy | PDT drug

Sonoflora 1

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205627

CAS#: 1609250-37-4

Description: Sonoflora 1, also known as SF1, a PDT photosensitivizer. Chemically, SF1 is an analog of chlorophyll in that its macrocycle backbone is porphyrin-based and the center of the porphyrin ring consists of a metal ion. Preclinical studies showed that SF1 had very high sonodynamic as well as photodynamic activity. The clinically tested results demonstrated positive therapeutic effects for treating patients with advanced refractory breast cancers that had failed to respond to conventional chemotherapy.

Chemical Structure

Sonoflora 1

CAS# 1609250-37-4

Handing Instruction

Theoretical Analysis

MedKoo Cat#: 205627
Name: Sonoflora 1
CAS#: 1609250-37-4
Chemical Formula: C38H42N6O10Sn
Exact Mass: 862.19844
Molecular Weight: 861.48
Elemental Analysis:

Size	Price	Shipping out time	Quantity
Inquire bulk and customized quantity Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Pricing updated 2021-03-08. Prices are subject to change without notice.

Sonoflora 1 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: Sonoflora 1; Sonoflora1; Sonoflora-1; SF1; SF-1; SF 1.

IUPAC/Chemical Name: Stannate(3-), [N-[2-[(7S,8S)-3-carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl-κN21,κN22,κN23,κN24]acetyl]glycylglycinato(5-)]dihydroxy-, sodium (1:3), (OC-6-13)-

InChi Key: YFKGEMWMQNGXOZ-IGVQWUNUSA-G

InChi Code: InChI=1S/C38H42N6O8.3Na.2H2O.Sn/c1-7-21-17(3)25-12-27-19(5)23(9-10-33(47)48)36(43-27)24(11-31(45)39-15-32(46)40-16-34(49)50)37-35(38(51)52)20(6)28(44-37)14-30-22(8-2)18(4)26(42-30)13-29(21)41-25;;;;;;/h7,12-14,19,23H,1,8-11,15-16H2,2-6H3,(H7,39,40,41,42,43,44,45,46,47,48,49,50,51,52);;;;2*1H2;/q;3*+1;;;+4/p-7/t19-,23-;;;;;;/m0....../s1

SMILES Code: O=C(NCC(NCC(O[Na])=O)=O)C/C1=C2[C@@H](CCC(O[Na])=O)[C@H](C)C(/C=C3C(C)=C(C=C)/C4=C/C(C(C)=C/5CC)=NC5=C/C6=C(C)C(C(O[Na])=O)=C1N6[Sn-2]([OH+])([OH+])N4/3)=N\2

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

2934.99.9001

Handling Instructions:

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 861.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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1: Wang X, Zhang W, Xu Z, Luo Y, Mitchell D, Moss RW. Sonodynamic and photodynamic therapy in advanced breast carcinoma: a report of 3 cases. Integr Cancer Ther. 2009 Sep;8(3):283-7. PubMed PMID: 19815599.

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Sonoflora 1

1g / Ask price

Additional Information

Sonodynamic therapy (SDT) has been developed as a complementary or alternative therapy to PDT. There are data to show that an additive effect might be obtained if SDT is combined with PDT. There are also data showing that PDT is synergistic with chemotherapeutic agents. In SDT treatment, patients first ingest a sonosensitizer, a drug that can be activated by ultrasound. This drug is then activated through the use of low-intensity ultrasound, producing a cascade of endogenous cytotoxic agents. The therapy is thus similar to PDT, except that the sensitizer is activated by ultrasound rather than by light. The body transmits ultrasound much more efficiently than light, and this is a decisive advantage when treating deeper tumors. ( Source: Integr Cancer Ther 8(3) (2009) 283)