Sonoflora 1

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MedKoo CAT#: 205627

CAS#: 1609250-37-4

Description: Sonoflora 1, also known as SF1, a PDT photosensitivizer. Chemically, SF1 is an analog of chlorophyll in that its macrocycle backbone is porphyrin-based and the center of the porphyrin ring consists of a metal ion. Preclinical studies showed that SF1 had very high sonodynamic as well as photodynamic activity. The clinically tested results demonstrated positive therapeutic effects for treating patients with advanced refractory breast cancers that had failed to respond to conventional chemotherapy.


Chemical Structure

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Sonoflora 1
CAS# 1609250-37-4

Theoretical Analysis

MedKoo Cat#: 205627
Name: Sonoflora 1
CAS#: 1609250-37-4
Chemical Formula: C38H42N6O10Sn
Exact Mass: 862.19844
Molecular Weight: 861.48
Elemental Analysis:

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Synonym: Sonoflora 1; Sonoflora1; Sonoflora-1; SF1; SF-1; SF 1.

IUPAC/Chemical Name: Stannate(3-​)​, [N-​[2-​[(7S,​8S)​-​3-​carboxy-​7-​(2-​carboxyethyl)​-​13-​ethenyl-​18-​ethyl-​2,​8,​12,​17-​tetramethyl-​21H,​23H-​porphin-​5-​yl-​κN21,​κN22,​κN23,​κN24]​acetyl]​glycylglycinato(5-​)​]​dihydroxy-​, sodium (1:3)​, (OC-​6-​13)​-

InChi Key: YFKGEMWMQNGXOZ-IGVQWUNUSA-G

InChi Code: InChI=1S/C38H42N6O8.3Na.2H2O.Sn/c1-7-21-17(3)25-12-27-19(5)23(9-10-33(47)48)36(43-27)24(11-31(45)39-15-32(46)40-16-34(49)50)37-35(38(51)52)20(6)28(44-37)14-30-22(8-2)18(4)26(42-30)13-29(21)41-25;;;;;;/h7,12-14,19,23H,1,8-11,15-16H2,2-6H3,(H7,39,40,41,42,43,44,45,46,47,48,49,50,51,52);;;;2*1H2;/q;3*+1;;;+4/p-7/t19-,23-;;;;;;/m0....../s1

SMILES Code: O=C(NCC(NCC(O[Na])=O)=O)C/C1=C2[C@@H](CCC(O[Na])=O)[C@H](C)C(/C=C3C(C)=C(C=C)/C4=C/C(C(C)=C/5CC)=NC5=C/C6=C(C)C(C(O[Na])=O)=C1N6[Sn-2]([OH+])([OH+])N4/3)=N\2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 861.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wang X, Zhang W, Xu Z, Luo Y, Mitchell D, Moss RW. Sonodynamic and photodynamic therapy in advanced breast carcinoma: a report of 3 cases. Integr Cancer Ther. 2009 Sep;8(3):283-7. PubMed PMID: 19815599.



Additional Information

 
Sonodynamic therapy (SDT) has been developed as a complementary or alternative therapy to PDT. There are data to show that an additive effect might be obtained if SDT is combined with PDT. There are also data showing that PDT is synergistic with chemotherapeutic agents. In SDT treatment, patients first ingest a sonosensitizer, a drug that can be activated by ultrasound. This drug is then activated through the use of low-intensity ultrasound, producing a cascade of endogenous cytotoxic agents. The therapy is thus similar to PDT, except that the sensitizer is activated by ultrasound rather than by light. The body transmits ultrasound much more efficiently than light, and this is a decisive advantage when treating deeper tumors. ( Source: Integr Cancer Ther 8(3) (2009) 283)