WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206094
CAS#: 931395-42-5
Description: Dusquetide, also known as SGX-942 and SGX94, is synthetic, 5-amino acid peptide and innate defense regulator (IDR), with immunomodulating, anti-inflammatory, anti-infective and anti-mucositis activities. Upon intravenous administration, SGX942 binds to the ZZ domain of sequestosome-1, also called p62, and activates regulatory signaling transduction pathways involved in the modulation of the innate immune system, such as those mediated by mitogen-activated protein kinase (MAPK) p38 and CCAAT-enhancer-binding protein.
MedKoo Cat#: 206094
Name: Dusquetide
CAS#: 931395-42-5
Chemical Formula: C25H47N9O5
Exact Mass: 553.37
Molecular Weight: 553.709
Elemental Analysis: C, 54.23; H, 8.56; N, 22.77; O, 14.45
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Synonym: SGX942; SGX942; SGX 942. SGX94; SGX-94; SGX 94; dusquetide; L-arginyl-L-isoleucyl-L-valyl-L-prolyl-L-alaninamide.
IUPAC/Chemical Name: (S)-1-(L-arginyl-L-isoleucyl-L-valyl)-N-((S)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide
InChi Key: ZUJBBVJXXYRPFS-DYKIIFRCSA-N
InChi Code: InChI=1S/C25H47N9O5/c1-6-14(4)19(33-21(36)16(26)9-7-11-30-25(28)29)23(38)32-18(13(2)3)24(39)34-12-8-10-17(34)22(37)31-15(5)20(27)35/h13-19H,6-12,26H2,1-5H3,(H2,27,35)(H,31,37)(H,32,38)(H,33,36)(H4,28,29,30)/t14-,15-,16-,17-,18-,19-/m0/s1
SMILES Code: C[C@@H](C(N)=O)NC([C@H]1N(C([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)N)=O)=O)=O)CCC1)=O
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 553.709 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kudrimoti M, Curtis A, Azawi S, Worden F, Katz S, Adkins D, Bonomi M, Elder J,
Sonis ST, Straube R, Donini O. Dusquetide: A novel innate defense regulator
demonstrating a significant and consistent reduction in the duration of oral
mucositis in preclinical data and a randomized, placebo-controlled phase 2a
clinical study. J Biotechnol. 2016 Oct 13;239:115-125. doi:
10.1016/j.jbiotec.2016.10.010. [Epub ahead of print] PubMed PMID: 27746305.
2: North JR, Takenaka S, Rozek A, Kielczewska A, Opal S, Morici LA, Finlay BB,
Schaber CJ, Straube R, Donini O. A novel approach for emerging and antibiotic
resistant infections: Innate defense regulators as an agnostic therapy. J
Biotechnol. 2016 May 20;226:24-34. doi: 10.1016/j.jbiotec.2016.03.032. PubMed
PMID: 27015977; PubMed Central PMCID: PMC4867239.
This agent promotes monocyte and macrophage recruitment to, and accelerates healing in damaged and infected tissue; it suppresses inflammation through the regulation of the expression of multiple cytokines. This agent may prevent or decrease chemo- or radiotherapy-induced mucositis as well as other types of infection. p62, an intracellular adaptor protein that functions downstream of certain signaling receptors, plays a key role in the activation of the innate immune system
