Rostaporfin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 202514

CAS#: 284041-10-7

Description: Rostaporfin (also known as REM-001, tin ethyl etiopurpurin, Sn(IV) etiopurpurin, Purlytin, SnET2), is a synthetic purpurin with photosensitizing activity. Rostaporfin preferentially accumulates in tumor cells due to an increased rate of metabolism. Upon exposure to a light source, this agent absorbs light, forming an extended high energy conformational state that produces high quantum yields of singlet oxygen with local cytotoxic effects.


Chemical Structure

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Rostaporfin
CAS# 284041-10-7

Theoretical Analysis

MedKoo Cat#: 202514
Name: Rostaporfin
CAS#: 284041-10-7
Chemical Formula: C37H42Cl2N4O2Sn
Exact Mass: 764.17068
Molecular Weight: 764.37
Elemental Analysis: C, 58.14; H, 5.54; Cl, 9.28; N, 7.33; O, 4.19; Sn, 15.53

Size Price Shipping out time Quantity
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Pricing updated 2021-03-08. Prices are subject to change without notice.

Rostaporfin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: SnET2; Sn(IV) etiopurpurin; Purlytin; tin ethyl etiopurpurin dichloride; tin etiopurpurin dichloride; Trademarks: Photrex; Purlytin; REM-001; REM 001; REM001;

IUPAC/Chemical Name: (OC-6-13)-Dichloro(rel-ethyl(18R,19S)-3,4,20,21-tetradehydro-4,9,14,19-tetraethyl-18,19-dihydro-3,8,13,18-tetramethyl-20-phorbinecarboxylato(2-)-kappaN(sup 23), kappaN(sup 24), kappaN(sup 25), kappaN(sup 26))tin

InChi Key: MSEVUQJXHVRVMJ-HQTZEDFWSA-M

InChi Code: InChI=1S/C37H43N4O2.2ClH.Sn/c1-10-23-19(6)29-17-33-25(12-3)21(8)34(40-33)26-15-27(36(42)43-14-5)37(13-4)22(9)30(41-35(26)37)18-32-24(11-2)20(7)28(39-32)16-31(23)38-29;;;/h15-18,22H,10-14H2,1-9H3,(H-,38,39,40,41,42);2*1H;/q-1;;;+2/p-1/t22-,37-;;;/m1.../s1

SMILES Code: CCC1=C(C2=CC3=C(C(=C4[N-]3[Sn+4]56(N2=C1C=C7[N-]5C8=C(C=C([C@]8([C@@H]7C)CC)C(=O)OCC)C9=N6C(=C4)C(=C9C)CC)([Cl-])[Cl-])C)CC)C

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 764.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sivaprasad S, Hykin P. The role of photodynamic therapy in ophthalmology. Br J Hosp Med (Lond). 2006 Dec;67(12):647-50. Review. PubMed PMID: 17328448.

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8: Jankun J, Lilge L, Douplik A, Keck RW, Pestka M, Szkudlarek M, Stevens PJ, Lee RJ, Selman SH. Optical characteristics of the canine prostate at 665 nm sensitized with tin etiopurpurin dichloride: need for real-time monitoring of photodynamic therapy. J Urol. 2004 Aug;172(2):739-43. PubMed PMID: 15247773.

9: Gloi AM, Beck E. Threshold dose of three photosensitizers in dogs with spontaneous tumors. Vet Ther. 2003 Fall;4(3):269-78. PubMed PMID: 15136988.

10: Rostaporfin: PhotoPoint SnET2, Purlytin, Sn(IV) etiopurpurin, SnET2, tin ethyl etiopurpurin. Drugs R D. 2004;5(1):58-61. Review. PubMed PMID: 14725496.

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17: Lim JI. Photodynamic therapy for choroidal neovascular disease: photosensitizers and clinical trials. Ophthalmol Clin North Am. 2002 Dec;15(4):473-8, vii. Review. PubMed PMID: 12515080.

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