WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 202490
Description: Ropidoxuridine is a novel, orally available, thymidine analogue and prodrug for IUdR, which demonstrated a survival advantage in Phase II studies in anaplastic astrocytoma, a type of glioma. Preclinical studies have also demonstrated that Ropidoxuridine has dose responsive and synergistic effects when combined with radiation in human glioblastoma models. Ropidoxuridine has also shown reduced toxicity, with better tissue incorporation and improved anti-tumor activity when compared to IUdR in nonclinical models. Ropidoxuridine was in clinical trials in patients with colorectal, gastric, and pancreatic cancer, and other solid tumors.
MedKoo Cat#: 202490
Chemical Formula: C9H11IN2O4
Exact Mass: 337.97635
Molecular Weight: 338.1
Elemental Analysis: C, 31.97; H, 3.28; I, 37.53; N, 8.29; O, 18.93
Ropidoxuridine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: IPdR; D08992; Ropidoxuridine; 5-Iodo-2-pyrimidinone-2-deoxyribose.
IUPAC/Chemical Name: 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one
InChi Key: XIJXHOVKJAXCGJ-XLPZGREQSA-N
InChi Code: InChI=1S/C9H11IN2O4/c10-5-2-11-9(15)12(3-5)8-1-6(14)7(4-13)16-8/h2-3,6-8,13-14H,1,4H2/t6-,7+,8+/m0/s1
SMILES Code: O=C1N=CC(I)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2
The following data is based on the product molecular weight 338.1 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
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6: Kinsella TJ, Kinsella MT, Hong S, Johnson JP, Burback B, Tosca PJ. Toxicology and pharmacokinetic study of orally administered 5-iodo-2-pyrimidinone-2'deoxyribose (IPdR) x 28 days in Fischer-344 rats: impact on the initial clinical phase I trial design of IPdR-mediated radiosensitization. Cancer Chemother Pharmacol. 2008 Feb;61(2):323-34. Epub 2007 Jun 12. PubMed PMID: 17562042.
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