Quinacrine hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 202385

CAS#: 69-05-6 (HCl)

Description: Quinacrine, aslo known as Mepacrine, is A 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53.

Chemical Structure

Quinacrine hydrochloride
CAS# 69-05-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 202385
Name: Quinacrine hydrochloride
CAS#: 69-05-6 (HCl)
Chemical Formula: C23H32Cl3N3O
Exact Mass:
Molecular Weight: 472.88
Elemental Analysis: C, 58.42; H, 6.82; Cl, 22.49; N, 8.89; O, 3.38

Size Price Shipping out time Quantity
1g USD 190 2 Weeks
5g USD 350 2 Weeks
10g USD 550 2 Weeks
20g USD 850 2 Weeks
50g USD 1150 2 Weeks
100g USD 1950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-01. Prices are subject to change without notice.

Quinacrine hydrochloride, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 10g may be 2 weeks.

Related CAS #: 83-89-6 (free base)   69-05-6 (HCl)   316-05-2 (mesylate)   6151-30-0 (HCl hydrate)   6598-46-5 (mesylate hydrate)    

Synonym: SN 390; SN-390; SN390; ST 439; Acrichine; Acrinamine; Acriquine; AI3-04467; Quinacrine dihydrochloride; mepacrine dihydrochoride. trade name: atabrine.

IUPAC/Chemical Name: N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride


InChi Code: InChI=1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H


Yellow solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in water (50mg/ mL)

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Certificate of Analysis:

Safety Data Sheet (SDS):

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 472.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Bhattacharyya S. Quinacrine sterilization (QS): the ethical issues. Int J Gynaecol Obstet. 2003 Oct;83 Suppl 2:S13-21. Review. PubMed PMID: 14763181.

2: Zipper J, Kessel E. Quinacrine sterilization: a retrospective. Int J Gynaecol Obstet. 2003 Oct;83 Suppl 2:S7-11. Review. PubMed PMID: 14763180.

3: Furukawa H, Takahashi M, Nakajima M, Yamada T. [Prospects of the therapeutic approaches to Creutzfeldt-Jakob disease: a clinical trial of antimalarial, quinacrine]. Nihon Rinsho. 2002 Aug;60(8):1649-57. Review. Japanese. PubMed PMID: 12187766.

4: Lippes J. Quinacrine sterilization: the imperative need for american clinical trials. Fertil Steril. 2002 Jun;77(6):1106-9. Review. PubMed PMID: 12057713.

5: Benagiano G. Non-surgical female sterilization with quinacrine: an update. Contraception. 2001 May;63(5):239-45. Review. PubMed PMID: 11448462.

Additional Information

Related CAS
CAS#69-05-6 ( Quinacrine HCl)
CAS#83-89-6 ( Quinacrine free).