WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 202385
CAS#: 69-05-6 (HCl)
Description: Quinacrine, aslo known as Mepacrine, is A 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53.
MedKoo Cat#: 202385
Name: Quinacrine hydrochloride
CAS#: 69-05-6 (HCl)
Chemical Formula: C23H32Cl3N3O
Exact Mass:
Molecular Weight: 472.88
Elemental Analysis: C, 58.42; H, 6.82; Cl, 22.49; N, 8.89; O, 3.38
Related CAS #: 83-89-6 (free base) 69-05-6 (HCl) 316-05-2 (mesylate) 6151-30-0 (HCl hydrate) 6598-46-5 (mesylate hydrate)
Synonym: SN 390; SN-390; SN390; ST 439; Acrichine; Acrinamine; Acriquine; AI3-04467; Quinacrine dihydrochloride; mepacrine dihydrochoride. trade name: atabrine.
IUPAC/Chemical Name: N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride
InChi Key: UDKVBVICMUEIKS-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
SMILES Code: CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.[H]Cl.[H]Cl
Appearance: Yellow solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in water (50mg/ mL)
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 472.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Bhattacharyya S. Quinacrine sterilization (QS): the ethical issues. Int J Gynaecol Obstet. 2003 Oct;83 Suppl 2:S13-21. Review. PubMed PMID: 14763181.
2: Zipper J, Kessel E. Quinacrine sterilization: a retrospective. Int J Gynaecol Obstet. 2003 Oct;83 Suppl 2:S7-11. Review. PubMed PMID: 14763180.
3: Furukawa H, Takahashi M, Nakajima M, Yamada T. [Prospects of the therapeutic approaches to Creutzfeldt-Jakob disease: a clinical trial of antimalarial, quinacrine]. Nihon Rinsho. 2002 Aug;60(8):1649-57. Review. Japanese. PubMed PMID: 12187766.
4: Lippes J. Quinacrine sterilization: the imperative need for american clinical trials. Fertil Steril. 2002 Jun;77(6):1106-9. Review. PubMed PMID: 12057713.
5: Benagiano G. Non-surgical female sterilization with quinacrine: an update. Contraception. 2001 May;63(5):239-45. Review. PubMed PMID: 11448462.
Related CAS
CAS#69-05-6 ( Quinacrine HCl)
CAS#83-89-6 ( Quinacrine free).
