Bimiralisib free base
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206146

CAS#: 1225037-39-7 (free base)

Description: Bimiralisib, also known as PQR309, is an orally bioavailable pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PQR309 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.


Chemical Structure

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Bimiralisib free base
CAS# 1225037-39-7 (free base)

Theoretical Analysis

MedKoo Cat#: 206146
Name: Bimiralisib free base
CAS#: 1225037-39-7 (free base)
Chemical Formula: C17H20F3N7O2
Exact Mass: 411.1631
Molecular Weight: 411.3892
Elemental Analysis: C, 49.63; H, 4.90; F, 13.85; N, 23.83; O, 7.78

Size Price Shipping out time Quantity
10mg USD 130 Same day
25mg USD 220 Same day
50mg USD 370 Same day
100mg USD 590 Same day
200mg USD 950 Same day
500mg USD 1900 Same day
1g USD 2650 2 weeks
2g USD 3950 2 weeks
5g USD 6350 2 weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-02. Prices are subject to change without notice.

Bimiralisib free base, purity > 98%, is in stock. The same day shipping out after order is received.

Related CAS #: 1820902-72-4 (HCl salt)   1225037-39-7 (free base)    

Synonym: PQR309; PQR-309; PQR309; Bimiralisib free base.

IUPAC/Chemical Name: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine

InChi Key: ADGGYDAFIHSYFI-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20F3N7O2/c18-17(19,20)12-9-13(21)22-10-11(12)14-23-15(26-1-5-28-6-2-26)25-16(24-14)27-3-7-29-8-4-27/h9-10H,1-8H2,(H2,21,22)

SMILES Code: NC1=NC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C(C(F)(F)F)=C1

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 411.3892 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 1: Big Hopes with Small Molecules - PIQUR Therapeutics AG is aiming to Turn
Cancer into a Manageable Disease. Chimia (Aarau). 2014 Dec;68(12):891-2. doi:
10.2533/chimia.2014.891. PubMed PMID: 26508614.