WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 202200

CAS#: 446022-33-9

Description: Pelitrexol is a GARFT inhibitor, and is also a water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation.

Chemical Structure

CAS# 446022-33-9

Theoretical Analysis

MedKoo Cat#: 202200
Name: Pelitrexol
CAS#: 446022-33-9
Chemical Formula: C20H25N5O6S
Exact Mass: 463.15255
Molecular Weight: 463.5074
Elemental Analysis: C, 51.83; H, 5.44; N, 15.11; O, 20.71; S, 6.92

Size Price Shipping out time Quantity
2mg USD 210 Same day
5mg USD 450 Same day
10mg USD 650 Same day
25mg USD 950 Same day
50mg USD 1650 Same day
100mg USD 2850 Same day
200mg USD 3950 Same day
Inquire bulk and customized quantity

Pricing updated 2021-03-02. Prices are subject to change without notice.

Pelitrexol, purity > 97%, is in stock. The same day shipping out after order is received.

Synonym: AG-2037; AG 2037; AG2037; Pelitrexol.

IUPAC/Chemical Name: (S)-2-(5-(2-((S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl)-4-methylthiophene-2-carboxamido)pentanedioic acid


InChi Code: InChI=1S/C20H25N5O6S/c1-9-6-14(18(29)23-12(19(30)31)3-5-15(26)27)32-13(9)4-2-10-7-11-16(22-8-10)24-20(21)25-17(11)28/h6,10,12H,2-5,7-8H2,1H3,(H,23,29)(H,26,27)(H,30,31)(H4,21,22,24,25,28)/t10-,12-/m0/s1

SMILES Code: O=C(O)[C@@H](NC(C1=CC(C)=C(CC[C@H](CN2)CC3=C2N=C(N)NC3=O)S1)=O)CCC(O)=O

white solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Preparing Stock Solutions

The following data is based on the product molecular weight 463.5074 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information