Pelitrexol
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 202200

CAS#: 446022-33-9

Description: Pelitrexol is a GARFT inhibitor, and is also a water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation.


Chemical Structure

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Pelitrexol
CAS# 446022-33-9

Theoretical Analysis

MedKoo Cat#: 202200
Name: Pelitrexol
CAS#: 446022-33-9
Chemical Formula: C20H25N5O6S
Exact Mass: 463.15255
Molecular Weight: 463.5074
Elemental Analysis: C, 51.83; H, 5.44; N, 15.11; O, 20.71; S, 6.92

Price and Availability

Size Price Availability Quantity
2.0mg USD 210.0 Same day
5.0mg USD 450.0 Same day
10.0mg USD 650.0 Same day
25.0mg USD 950.0 Same day
50.0mg USD 1650.0 Same day
100.0mg USD 2850.0 Same day
200.0mg USD 3950.0 Same day
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Synonym: AG-2037; AG 2037; AG2037; Pelitrexol.

IUPAC/Chemical Name: (S)-2-(5-(2-((S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl)-4-methylthiophene-2-carboxamido)pentanedioic acid

InChi Key: QXOPTIPQEVJERB-JQWIXIFHSA-N

InChi Code: InChI=1S/C20H25N5O6S/c1-9-6-14(18(29)23-12(19(30)31)3-5-15(26)27)32-13(9)4-2-10-7-11-16(22-8-10)24-20(21)25-17(11)28/h6,10,12H,2-5,7-8H2,1H3,(H,23,29)(H,26,27)(H,30,31)(H4,21,22,24,25,28)/t10-,12-/m0/s1

SMILES Code: O=C(O)[C@@H](NC(C1=CC(C)=C(CC[C@H](CN2)CC3=C2N=C(N)NC3=O)S1)=O)CCC(O)=O

Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 463.5074 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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