DOTA
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MedKoo CAT#: 126013

CAS#: 60239-18-1

Description: DOTA is an azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group. It has a role as a chelator and a copper chelator. It derives from a hydride of a 1,4,7,10-tetraazacyclododecane. It is a a metal chelate in use in medical diagnostics.


Chemical Structure

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DOTA
CAS# 60239-18-1

Theoretical Analysis

MedKoo Cat#: 126013
Name: DOTA
CAS#: 60239-18-1
Chemical Formula: C16H28N4O8
Exact Mass: 404.19
Molecular Weight: 404.420
Elemental Analysis: C, 47.52; H, 6.98; N, 13.85; O, 31.65

Price and Availability

Size Price Availability Quantity
1g USD 350 Ready to ship
5g USD 550 Ready to ship
10g USD 750 2 weeks
25g USD 1250 2 weeks
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Synonym: DOTA; Tetraxetan; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid; Dota acid;

IUPAC/Chemical Name: 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid

InChi Key: WDLRUFUQRNWCPK-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)

SMILES Code: C1CN(CCN(CCN(CCN1CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O

Appearance: To be determined

Purity: >97% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 404.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Stasiuk GJ, Long NJ. The ubiquitous DOTA and its derivatives: the impact of
1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid on biomedical imaging.
Chem Commun (Camb). 2013 Apr 7;49(27):2732-46. doi: 10.1039/c3cc38507h. PMID:
23392443.

2: Sneddon D, Cornelissen B. Emerging chelators for nuclear imaging. Curr Opin
Chem Biol. 2021 Aug;63:152-162. doi: 10.1016/j.cbpa.2021.03.001. Epub 2021 May
26. PMID: 34051509.

3: Kahnt M, Hoenke S, Fischer L, Al-Harrasi A, Csuk R. Synthesis and
Cytotoxicity Evaluation of DOTA-Conjugates of Ursolic Acid. Molecules. 2019 Jun
17;24(12):2254. doi: 10.3390/molecules24122254. PMID: 31212958; PMCID:
PMC6630699.