WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 205742
Description: NKP-2235, also known as IT-235, is a first-in-class orally available gallium-based anticaner small molecule that targets the endoplasmic reticulum with a unique pattern of cytotoxicity. NKP-2235 IND has been cleared and a Phase I trial will be initiated shortly. NKP-2235 were discovered by Professor Bernhard Keppler, University of Vienna, Austria.
MedKoo Cat#: 205742
NKP-2235 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: NKP2235; NKP 2235; NKP-2235; IT-235; IT235; IT 235.
IUPAC/Chemical Name: NONE
The following data is based on the product molecular weight Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
NKP-2235 is a first-in-class targeted gallium-based small molecule. It is orally bioavailable and given as a tablet. NKP-2235, is currently being developed by Niiki Pharma. According to its website, NKP-2235 targets the endoplasmic reticulum. Unlike normal cells, tumor cells are known to be under high levels of stress due to factors such as hypoxia, acidosis and glucose deprivation. This leads to high levels of protein misfolding and other stress effects. Endoplasmic reticulum is the cell machinery that repairs protein misfolding. In tumor cells, the endoplasmic reticulum in is under stress due to the high levels of misfolded proteins and other factors. NKP-2235 induces additional endoplasmic reticulum stress, leading to an overload of the system, which triggers tumor cell death.