NKP-2235

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205742

CAS#: NONE

Description: NKP-2235, also known as IT-235, is a first-in-class orally available gallium-based anticaner small molecule that targets the endoplasmic reticulum with a unique pattern of cytotoxicity. NKP-2235 IND has been cleared and a Phase I trial will be initiated shortly. NKP-2235 were discovered by Professor Bernhard Keppler, University of Vienna, Austria.


Chemical Structure

No image available
NKP-2235
CAS# NONE

Theoretical Analysis

MedKoo Cat#: 205742
Name: NKP-2235
CAS#: NONE
Chemical Formula:
Exact Mass:
Molecular Weight:
Elemental Analysis:

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2021-02-25. Prices are subject to change without notice.

NKP-2235 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: NKP2235; NKP 2235; NKP-2235; IT-235; IT235; IT 235.

IUPAC/Chemical Name: NONE

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x



Additional Information

NKP-2235 is a first-in-class targeted gallium-based small molecule. It is orally bioavailable and given as a tablet. NKP-2235, is currently being developed by Niiki Pharma. According to its website,  NKP-2235 targets the endoplasmic reticulum. Unlike normal cells, tumor cells are known to be under high levels of stress due to factors such as hypoxia, acidosis and glucose deprivation. This leads to high levels of protein misfolding and other stress effects. Endoplasmic reticulum is the cell machinery that repairs protein misfolding. In tumor cells, the endoplasmic reticulum in is under stress due to the high levels of misfolded proteins and other factors. NKP-2235 induces additional endoplasmic reticulum stress, leading to an overload of the system, which triggers tumor cell death.