Hynic-TOC
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MedKoo CAT#: 125681

CAS#: 257943-19-4

Description: Hynic-TOC is a ligand for making 99mTc-Hynic-TOC as an imaging agent in the diagnostic of neuroendocrine tumor.


Chemical Structure

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Hynic-TOC
CAS# 257943-19-4

Theoretical Analysis

MedKoo Cat#: 125681
Name: Hynic-TOC
CAS#: 257943-19-4
Chemical Formula: C55H71N13O12S2
Exact Mass: 1,169.48
Molecular Weight: 1,170.370
Elemental Analysis: C, 56.44; H, 6.11; N, 15.56; O, 16.40; S, 5.48

Price and Availability

Size Price Availability Quantity
5mg USD 1650 2 Weeks
10mg USD 2950 2 Weeks
100mg USD 6950 2 Weeks
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Synonym: HYNIC-Tyr3-octreotide; Hynic-TOC; HynicTOC; Hynic TOC; Hydrazinonicotinyl-Tyr3-octreotide

IUPAC/Chemical Name: (4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-10-(4-aminobutyl)-N-((2R,3R)-1,3-dihydroxybutan-2-yl)-19-((R)-2-((E)-6-hydrazineylidene-1,6-dihydropyridine-3-carboxamido)-3-phenylpropanamido)-16-(4-hydroxybenzyl)-7-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide

InChi Key: WJBPMDZACHSXSD-HLAGHTPDSA-N

InChi Code: InChI=1S/C55H71N13O12S2/c1-30(70)43(27-69)64-54(79)45-29-82-81-28-44(65-51(76)40(22-32-10-4-3-5-11-32)61-48(73)34-17-20-46(68-57)59-25-34)53(78)62-41(23-33-15-18-36(72)19-16-33)50(75)63-42(24-35-26-58-38-13-7-6-12-37(35)38)52(77)60-39(14-8-9-21-56)49(74)67-47(31(2)71)55(80)66-45/h3-7,10-13,15-20,25-26,30-31,39-45,47,58,69-72H,8-9,14,21-24,27-29,56-57H2,1-2H3,(H,59,68)(H,60,77)(H,61,73)(H,62,78)(H,63,75)(H,64,79)(H,65,76)(H,66,80)(H,67,74)/t30-,31-,39+,40-,41+,42-,43-,44+,45+,47+/m1/s1

SMILES Code: O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)C(N[C@H](CO)[C@H](O)C)=O)NC([C@H](NC(C(C=C/2)=CNC2=N\N)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=C(C=C4)O)N[C@@H]1CC5=CNC6=CC=CC=C56

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,170.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Briganti V, Cuccurullo V, Berti V, Di Stasio GD, Linguanti F, Mungai F, Mansi
L. 99mTc-EDDA/HYNIC-TOC is a New Opportunity in Neuroendocrine Tumors
of the Lung (and in other Malignant and Benign Pulmonary Diseases). Curr
Radiopharm. 2020;13(3):166-176. doi: 10.2174/1874471013666191230143610. PMID:
31886756; PMCID: PMC8193811.

2: Garai I, Barna S, Nagy G, Forgacs A. Limitations and pitfalls of 99mTc-
EDDA/HYNIC-TOC (Tektrotyd) scintigraphy. Nucl Med Rev Cent East Eur.
2016;19(2):93-8. doi: 10.5603/NMR.2016.0019. PMID: 27479887.

3: Shi X, Jing H, Li F, Zhao Y, Wang Z, Huo L. 99mTc-HYNIC-TOC in the Evaluation
of Recurrent Tumor-Induced Osteomalacia. Clin Nucl Med. 2019 Mar;44(3):209-213.
doi: 10.1097/RLU.0000000000002458. PMID: 30672760.

4: Li B, Duan L, Li X, Shi J, Li H, Liu H, Cheng X, Wu X, Gao Y. Diagnostic
accuracy of 99mTc-HYNIC-TOC SPECT/CT for detecting osteomalacia-
associated tumors. Front Oncol. 2023 Jul 24;13:1228575. doi:
10.3389/fonc.2023.1228575. PMID: 37554164; PMCID: PMC10405922.

5: Liepe K, Becker A. 99mTc-Hynic-TOC imaging in the diagnostic of
neuroendocrine tumors. World J Nucl Med. 2018 Jul-Sep;17(3):151-156. doi:
10.4103/wjnm.WJNM_41_17. PMID: 30034278; PMCID: PMC6034543.

6: Chaib S, Hallouard F, Chennell P, Darcissac C, Morelec I, Rioufol C, Sautou
V, Fraysse M. Compatibility of [99mTc]Tc-EDDA/HYNIC-TOC and [68Ga] Ga-DOTA-TOC
in a syringe for intravenous administration. Nucl Med Commun. 2020
Jan;41(1):11-17. doi: 10.1097/MNM.0000000000001108. PMID: 31764593.

7: Hou G, Jiang Y, Li F, Zhu Z, Jing H. Site-based performance of 131I-MIBG
imaging and 99mTc-HYNIC-TOC scintigraphy in the detection of nonmetastatic
extra-adrenal paraganglioma. Nucl Med Commun. 2022 Jan 1;43(1):32-41. doi:
10.1097/MNM.0000000000001490. PMID: 34570039; PMCID: PMC8654250.

8: Gherghe M, Lazăr AM, Stanciu AE, Mutuleanu MD, Sterea MC, Petroiu C, Galeș
LN. The New Radiolabeled Peptide 99mTcEDDA/HYNIC-TOC: Is It a
Feasible Choice for Diagnosing Gastroenteropancreatic NETs? Cancers (Basel).
2022 May 31;14(11):2725. doi: 10.3390/cancers14112725. PMID: 35681704; PMCID:
PMC9179571.

9: Sager S, Kabasakal L, Halac M, Maecke H, Uslu L, Önsel Ç, Kanmaz B.
Comparison of 99mTc-HYNIC-TOC and HYNIC-TATE octreotide scintigraphy with FDG
PET and 99mTc-MIBI in local recurrent or distant metastatic thyroid cancers.
Clin Nucl Med. 2013 May;38(5):321-5. doi: 10.1097/RLU.0b013e3182868062. PMID:
23531772.

10: Boutsikou E, Porpodis K, Chatzipavlidou V, Hardavella G, Gerasimou G, Domvri
K, Papadopoulos N, Avramidou V, Spyratos D, Kontakiotis T, Zarogoulidis K.
Predictive Value of 99MTC-hynic-toc Scintigraphy in Lung Neuroendocrine Tumor
Diagnosis. Technol Cancer Res Treat. 2019 Jan 1;18:1533033819842586. doi:
10.1177/1533033819842586. PMID: 31079574; PMCID: PMC6535698.