NOTA-NFB
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125678

CAS#: N/A

Description: NOTA-NFB is a ligand for making radioactive complex 68Ga-NOTA-NFB, which is am imaging agent and a tracer for CXCR4 evaluation in glioma patients after measuring the dosimetry of 68Ga-NOTA-NFB in healthy volunteers.


Chemical Structure

img
NOTA-NFB
CAS# N/A

Theoretical Analysis

MedKoo Cat#: 125678
Name: NOTA-NFB
CAS#: N/A
Chemical Formula: C102H163DN37O23S4
Exact Mass: 2,404.17
Molecular Weight: 2,405.920
Elemental Analysis: C, 50.92; H, 6.91; N, 21.54; O, 15.29; S, 5.33

Price and Availability

Size Price Availability Quantity
5mg USD 1650 2 Weeks
10mg USD 2950 2 Weeks
100mg USD 6950 2 Weeks
Bulk inquiry

Synonym: NOTA-NFB; NOTANFB; NOTA NFB

IUPAC/Chemical Name: N/A

InChi Key:

InChi Code:

SMILES Code: O=C(NN[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C([Nal](SS[Cys](N[C@@H](CCCNC(N)=N)C(N)=O)N[C@H]1CCCNC(N)=O)N[C@@H](CS)C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C([Lys](N3CCC[C@H]3C([Arg](N[C@@H](CC4=CC=C(O)C=C4)C=O)C1=O)=O)[DLys])=O)CCCNC(N)=O)=O)=O)=O)=O)CN5CCN(CC(O)=O)CCN(CC(O)=O)CC5

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 2,405.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Leung K. 64Cu-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic
acid-Arg-Arg-Natl-Cys-Tyr-Cit-Lys-d-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-NH2.
2011 Nov 15 [updated 2012 Feb 9]. In: Molecular Imaging and Contrast Agent
Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology
Information (US); 2004–2013. PMID: 22338195.

2: Wang Z, Zhang M, Wang L, Wang S, Kang F, Li G, Jacobson O, Niu G, Yang W,
Wang J, Chen X. Prospective Study of (68)Ga-NOTA-NFB: Radiation Dosimetry in
Healthy Volunteers and First Application in Glioma Patients. Theranostics. 2015
Apr 28;5(8):882-9. doi: 10.7150/thno.12303. PMID: 26000059; PMCID: PMC4440444.

3: Leung K. 64Cu-1,4,7-Triazacyclononane-1,4,7-triacetic acid-Arg-
Arg-Natl-Cys-Tyr-Cit-Lys-d-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-NH2. 2011 Nov
15 [updated 2012 Feb 9]. In: Molecular Imaging and Contrast Agent Database
(MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information
(US); 2004–2013. PMID: 22338192.

4: Jacobson O, Weiss ID, Szajek LP, Niu G, Ma Y, Kiesewetter DO, Peled A, Eden
HS, Farber JM, Chen X. Improvement of CXCR4 tracer specificity for PET imaging.
J Control Release. 2012 Jan 30;157(2):216-23. doi:
10.1016/j.jconrel.2011.09.076. Epub 2011 Sep 22. PMID: 21964282; PMCID:
PMC3259211.