WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125676


Description: DOTA-c(RGDyK) is useful ligand for making 225Ac-DOTA-c(RGDyK), which is a potential radiopharmaceutical for targeted alpha particle therapy.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 125676
Name: DOTA-c(RGDyK)
Chemical Formula: C43H67N13O15
Exact Mass: 1,005.49
Molecular Weight: 1,006.090
Elemental Analysis: C, 51.33; H, 6.71; N, 18.10; O, 23.85

Price and Availability

Size Price Availability Quantity
10mg USD 1250 2 Weeks
50mg USD 2050 2 Weeks
100mg USD 3850 2 Weeks
Bulk inquiry

Synonym: DOTA-c(RGDyK); DOTA c(RGDyK); DOTA-c-(RGDyK)

IUPAC/Chemical Name: 2,2',2''-(10-(2-((4-(11-(carboxymethyl)-5-(3-guanidinopropyl)-14-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)butyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid


InChi Code: InChI=1S/C43H67N13O15/c44-43(45)47-11-3-5-29-39(68)48-22-33(58)49-32(21-35(60)61)42(71)52-31(20-27-6-8-28(57)9-7-27)41(70)51-30(40(69)50-29)4-1-2-10-46-34(59)23-53-12-14-54(24-36(62)63)16-18-56(26-38(66)67)19-17-55(15-13-53)25-37(64)65/h6-9,29-32,57H,1-5,10-26H2,(H,46,59)(H,48,68)(H,49,58)(H,50,69)(H,51,70)(H,52,71)(H,60,61)(H,62,63)(H,64,65)(H,66,67)(H4,44,45,47)


Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,006.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Pandya DN, Hantgan R, Budzevich MM, Kock ND, Morse DL, Batista I, Mintz A, Li KC, Wadas TJ. Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization. Theranostics. 2016 Mar 1;6(5):698-709. doi: 10.7150/thno.14338. PMID: 27022417; PMCID: PMC4805664.