NOTA-E(cRGDfK)2
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MedKoo CAT#: 125675

CAS#: N/A

Description: NOTA-E(cRGDfK)2 is a ligand to making 68Ga-DOTA-E[c(RGDfK)]2, which is a PET Imaging agent of SHARPIN-Regulated Integrin Activity. E[c(RGDfk)]2 = glutamic acid-[cyclo(arginyl-glycyl-aspartic acid-D-phenylalanine-lysine).


Chemical Structure

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NOTA-E(cRGDfK)2
CAS# N/A

Theoretical Analysis

MedKoo Cat#: 125675
Name: NOTA-E(cRGDfK)2
CAS#: N/A
Chemical Formula: C79H113N23O22S
Exact Mass: 1,767.82
Molecular Weight: 1,768.970
Elemental Analysis: C, 53.64; H, 6.44; N, 18.21; O, 19.90; S, 1.81

Price and Availability

Size Price Availability Quantity
10mg USD 1250 2 Weeks
50mg USD 2050 2 Weeks
100mg USD 3850 2 Weeks
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Synonym: NOTA-E(cRGDfK)2; NOTA E(cRGDfK)2; NOTA-E(cRGDfK)-2

IUPAC/Chemical Name: 2,2',2''-(2-(4-(3-((S)-1,5-bis((4-((2S,5S,11S,14R)-14-benzyl-11-(carboxymethyl)-5-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)butyl)amino)-1,5-dioxopentan-2-yl)thioureido)benzyl)-1,4,7-triazonane-1,4,7-triyl)triacetic acid

InChi Key: MKQVHBJEKOTOJY-JGSRZCFOSA-N

InChi Code: InChI=1S/C79H113N23O22S/c80-77(81)86-29-11-19-51-69(117)88-40-61(104)91-58(38-63(106)107)75(123)97-56(36-46-13-3-1-4-14-46)73(121)95-53(71(119)93-51)17-7-9-27-84-60(103)26-25-55(99-79(125)90-49-23-21-48(22-24-49)35-50-42-101(44-66(112)113)32-31-100(43-65(110)111)33-34-102(50)45-67(114)115)68(116)85-28-10-8-18-54-72(120)94-52(20-12-30-87-78(82)83)70(118)89-41-62(105)92-59(39-64(108)109)76(124)98-57(74(122)96-54)37-47-15-5-2-6-16-47/h1-6,13-16,21-24,50-59H,7-12,17-20,25-45H2,(H,84,103)(H,85,116)(H,88,117)(H,89,118)(H,91,104)(H,92,105)(H,93,119)(H,94,120)(H,95,121)(H,96,122)(H,97,123)(H,98,124)(H,106,107)(H,108,109)(H,110,111)(H,112,113)(H,114,115)(H4,80,81,86)(H4,82,83,87)(H2,90,99,125)/t50?,51-,52-,53-,54-,55-,56+,57+,58-,59-/m0/s1

SMILES Code: O=C(NCCCC[C@@H]1NC([C@H](NC([C@@H](NC(CNC([C@H](CCCNC(N)=N)NC1=O)=O)=O)CC(O)=O)=O)CC2=CC=CC=C2)=O)CC[C@H](NC(NC3=CC=C(CC4N(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)C4)C=C3)=S)C(NCCCC[C@@H]5NC([C@H](NC([C@@H](NC(CNC([C@H](CCCNC(N)=N)NC5=O)=O)=O)CC(O)=O)=O)CC6=CC=CC=C6)=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,768.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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