WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206071
Description: Mureletecan is a water-soluble prodrug, consisting of camptothecin covalently linked to polymeric backbone methacryloylglycynamide, with potential antineoplastic activity. After entering tumor cells, the active moiety camptothecin is slowly released from mureletecan via hydrolysis of the ester linkage. Camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, binds to and stabilizes the topoisomerase I-DNA covalent complex. This inhibits the religation of topoisomerase I-mediated single-stranded DNA breaks and produces potentially lethal double-stranded DNA breaks when encountered by the DNA replication machinery, resulting in the inhibition of DNA replication and apoptosis. Compared to camtpothecin, this prodrug formulation increases camptothecin drug delivery to the tumor site while reducing systemic toxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
MedKoo Cat#: 206071
Chemical Formula: Unknown
Exact Mass: 0.0
Molecular Weight: 0.0
Elemental Analysis: Unknown
Synonym: Mureletecan; PNU166148; PNU 166148; PNU-166148; MAGCPT; MAG CPT; MAG-CPT
IUPAC/Chemical Name: Unknown
1: Duncan R, Vicent MJ. Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities. Adv Drug Deliv Rev. 2010 Feb 17;62(2):272-82. doi: 10.1016/j.addr.2009.12.005. Epub 2009 Dec 11. Review. PubMed PMID: 20005271.
2: Duncan R. Development of HPMA copolymer-anticancer conjugates: clinical experience and lessons learnt. Adv Drug Deliv Rev. 2009 Nov 12;61(13):1131-48. doi: 10.1016/j.addr.2009.05.007. Epub 2009 Aug 20. Review. PubMed PMID: 19699249.
3: Bissett D, Cassidy J, de Bono JS, Muirhead F, Main M, Robson L, Fraier D, MagnÃ¨ ML, Pellizzoni C, Porro MG, Spinelli R, Speed W, Twelves C. Phase I and pharmacokinetic (PK) study of MAG-CPT (PNU 166148): a polymeric derivative of camptothecin (CPT). Br J Cancer. 2004 Jul 5;91(1):50-5. PubMed PMID: 15187995; PubMed Central PMCID: PMC2364737.