BML-278
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125387

CAS#: 120533-76-8

Description: BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM.

Chemical Structure

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BML-278
CAS# 120533-76-8
Instruction

Theoretical Analysis

MedKoo Cat#: 125387
Name: BML-278
CAS#: 120533-76-8
Chemical Formula: C24H25NO4
Exact Mass: 391.18
Molecular Weight: 391.470
Elemental Analysis: C, 73.64; H, 6.44; N, 3.58; O, 16.35

Price and Availability

Size Price Availability Quantity
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2950 2 Weeks
2g USD 5250 2 Weeks
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Synonym: BML-278; BML 278; BML278; diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate; Diethyl 1-benzyl-4-phenyl-4H-pyridine-3,5-dicarboxylate

IUPAC/Chemical Name: diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key: JOHFECBOWRGWJZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H25NO4/c1-3-28-23(26)20-16-25(15-18-11-7-5-8-12-18)17-21(24(27)29-4-2)22(20)19-13-9-6-10-14-19/h5-14,16-17,22H,3-4,15H2,1-2H3

SMILES Code: O=C(OCC)C1=CN(CC2=CC=CC=C2)C=C(C(OCC)=O)C1C3=CC=CC=C3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 391.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Adamkova K, Yi YJ, Petr J, Zalmanova T, Hoskova K, Jelinkova P, Moravec J, Kralickova M, Sutovsky M, Sutovsky P, Nevoral J. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotechnol. 2017 Nov 1;8:83. doi: 10.1186/s40104-017-0214-0. PMID: 29118980; PMCID: PMC5664433.