MK-1496

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205537

CAS#: 1037254-47-9 (free base)

Description: MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).


Chemical Structure

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MK-1496
CAS# 1037254-47-9 (free base)

Theoretical Analysis

MedKoo Cat#: 205537
Name: MK-1496
CAS#: 1037254-47-9 (free base)
Chemical Formula: C14H24N2O
Exact Mass: 236.1889
Molecular Weight: 236.359
Elemental Analysis: C, 71.14; H, 10.24; N, 11.85; O, 6.77

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Related CAS #: 1037252-20-2 (SR-isomer)   1037254-47-9 (free base)    

Synonym: MK-1496; MK1496; MK 1496.

IUPAC/Chemical Name: (1S)-1-(4-((1S)-1-Aminoethyl)phenyl)-2-(tert-butylamino)ethanol

InChi Key: KUHBBYPXWKYKKR-GXFFZTMASA-N

InChi Code: InChI=1S/C14H24N2O/c1-10(15)11-5-7-12(8-6-11)13(17)9-16-14(2,3)4/h5-8,10,13,16-17H,9,15H2,1-4H3/t10-,13+/m0/s1

SMILES Code: CC(NC[C@@H](O)C1=CC=C([C@@H](N)C)C=C1)(C)C

Appearance: Solid powder

Purity: >98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 236.359 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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MK-1496

10.0mg / Not available


Additional Information