WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125225

CAS#: 856702-40-4

Description: CBiPES HCl is a selective positive allosteric modulator of the mGlu2 receptor.

Chemical Structure

CAS# 856702-40-4

Theoretical Analysis

MedKoo Cat#: 125225
Name: CBiPES HCl
CAS#: 856702-40-4
Chemical Formula: C21H20ClN3O2S
Exact Mass: 413.10
Molecular Weight: 413.920
Elemental Analysis: C, 60.94; H, 4.87; Cl, 8.56; N, 10.15; O, 7.73; S, 7.75

Price and Availability

Size Price Availability Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3850 2 Weeks
2g USD 5950 2 Weeks
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Synonym: CBiPES hydrochloride; 856702-40-4; DL3XSQ69E9; CBiPES (hydrochloride); UNII-DL3XSQ69E9

IUPAC/Chemical Name: N-(4'-cyano-[1,1'-biphenyl]-3-yl)-N-(pyridin-3-ylmethyl)ethanesulfonamide hydrochloride


InChi Code: InChI=1S/C21H19N3O2S.ClH/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19;/h3-13,15H,2,16H2,1H3;1H

SMILES Code: O=S(N(CC2=CC=CN=C2)C1=CC(C3=CC=C(C#N)C=C3)=CC=C1)(CC)=O.Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 413.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Frouni I, Kwan C, Nuara SG, Belliveau S, Kang W, Hamadjida A, Bédard D,
Gourdon JC, Huot P. Effect of the mGlu2 positive allosteric modulator
CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-
lesioned marmoset. J Neural Transm (Vienna). 2021 Jan;128(1):73-81. doi:
10.1007/s00702-020-02287-8. Epub 2021 Jan 3. PMID: 33392826.

2: Benvenga MJ, Chaney SF, Baez M, Britton TC, Hornback WJ, Monn JA, Marek GJ.
Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head
Twitches Induced by a Serotonergic Hallucinogen in Mice. Front Pharmacol. 2018
Mar 15;9:208. doi: 10.3389/fphar.2018.00208. PMID: 29599719; PMCID: PMC5862811.

3: Caulder EH, Riegle MA, Godwin DW. Activation of group 2 metabotropic
glutamate receptors reduces behavioral and electrographic correlates of
pilocarpine induced status epilepticus. Epilepsy Res. 2014 Feb;108(2):171-81.
doi: 10.1016/j.eplepsyres.2013.10.009. Epub 2013 Nov 16. PMID: 24305700; PMCID:

4: Johnson PL, Fitz SD, Engleman EA, Svensson KA, Schkeryantz JM, Shekhar A.
Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent
sodium lactate-induced panic-like response in panic-vulnerable rats. J
Psychopharmacol. 2013 Feb;27(2):152-61. doi: 10.1177/0269881112454230. Epub 2012
Aug 21. PMID: 22914798; PMCID: PMC4300988.

5: Johnson MP, Barda D, Britton TC, Emkey R, Hornback WJ, Jagdmann GE, McKinzie
DL, Nisenbaum ES, Tizzano JP, Schoepp DD. Metabotropic glutamate 2 receptor
potentiators: receptor modulation, frequency-dependent synaptic activity, and
efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology
(Berl). 2005 Apr;179(1):271-83. doi: 10.1007/s00213-004-2099-9. Epub 2005 Feb
17. PMID: 15717213.