SKF-91488 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125223

CAS#: 68941-21-9

Description: SKF 91488 dihydrochloride is a homolog of dimaprit.

Chemical Structure

SKF-91488 HCl
CAS# 68941-21-9

Theoretical Analysis

MedKoo Cat#: 125223
Name: SKF-91488 HCl
CAS#: 68941-21-9
Chemical Formula: C7H19Cl2N3S
Exact Mass: 247.07
Molecular Weight: 248.210
Elemental Analysis: C, 33.87; H, 7.72; Cl, 28.56; N, 16.93; S, 12.92

Price and Availability

Size Price Availability Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3850 2 Weeks
2g USD 5950 2 Weeks
Bulk inquiry

Synonym: SKF 91488 dihydrochloride; SKF 91488 HCl; SKF91488 HCl; SKF 91488 dihydrochloride

IUPAC/Chemical Name: 4-(dimethylamino)butyl carbamimidothioate dihydrochloride


InChi Code: InChI=1S/C7H17N3S.2ClH/c1-10(2)5-3-4-6-11-7(8)9;;/h3-6H2,1-2H3,(H3,8,9);2*1H


Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 248.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jochem J, Zwirska-Korczala K, Rybus-Kalinowska B, Jagodzińska J, Korzonek-
Szlacheta I. Influence of SKF 91488, histamine N-methyltransferase inhibitor, on
the central cardiovascular regulation during controlled, stepwise hemorrhagic
hypotension in rats. Pol J Pharmacol. 2002 May-Jun;54(3):237-44. PMID: 12398155.

2: Malmberg-Aiello P, Lamberti C, Ipponi A, Hänninen J, Ghelardini C, Bartolini
A. Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301
U, in rodent antinociception. Naunyn Schmiedebergs Arch Pharmacol. 1997
Mar;355(3):354-60. doi: 10.1007/pl00004954. PMID: 9089666.

3: Jochem J. Endogenous central histamine-induced reversal of critical
haemorrhagic hypotension in rats--studies with histamine N-methyltransferase
inhibitor SKF 91488. Inflamm Res. 2002 Nov;51(11):551-6. doi:
10.1007/pl00012426. PMID: 12540019.

4: Klein MC, Gertner SB. Evidence for a role of endogenous histamine in central
cardiovascular regulation: inhibition of histamine-N-methyltransferase by SKF
91488. J Pharmacol Exp Ther. 1981 Feb;216(2):315-20. PMID: 6450831.

5: Nakazawa H, Sekizawa K, Morikawa M, Yamauchi K, Satoh M, Maeyama K, Watanabe
T, Sasaki H. Viral respiratory infection causes airway hyperresponsiveness and
decreases histamine N-methyltransferase activity in guinea pigs. Am J Respir
Crit Care Med. 1994 May;149(5):1180-5. doi: 10.1164/ajrccm.149.5.8173757. PMID: