ME-344

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205856

CAS#: 1374524-55-6

Description: ME-344 is an active metabolite of NV-128, a novel flavonoid small molecule inhibitor of the mammalian Target of Rapamycin (mTOR), with potential antineoplastic activity. Upon administration, mTOR1/2 Kinase inhibitor ME-344 downregulates the PIK3/AKT/mTOR pathway and results in chromatin condensation in the absence of caspase activation. Consequently, this agent induces caspase-independent cell death in tumor cells with a de-regulated PIK3/AKT/mTOR pathway or chemotherapeutic resistant cells. In pre-clinical studies, ME-344 has shown tenfold more anti-tumor activity than NV-128.


Chemical Structure

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ME-344
CAS# 1374524-55-6

Theoretical Analysis

MedKoo Cat#: 205856
Name: ME-344
CAS#: 1374524-55-6
Chemical Formula: C22H20O4
Exact Mass: 348.13616
Molecular Weight: 348.39
Elemental Analysis: C, 75.84; H, 5.79; O, 18.37

Size Price Shipping out time Quantity
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Pricing updated 2021-03-06. Prices are subject to change without notice.

ME-344 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: ME-344; ME 344; ME344.

IUPAC/Chemical Name: 4,4'-(7-hydroxy-8-methylchroman-3,4-diyl)diphenol.

InChi Key: QVCAATSEPLQVBX-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20O4/c1-13-20(25)11-10-18-21(15-4-8-17(24)9-5-15)19(12-26-22(13)18)14-2-6-16(23)7-3-14/h2-11,19,21,23-25H,12H2,1H3

SMILES Code: CC1=C(O)C=CC2=C1OCC(C3=CC=C(O)C=C3)C2C4=CC=C(O)C=C4

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 348.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 1: Lim SC, Carey KT, McKenzie M. Anti-cancer analogues ME-143 and ME-344 exert
toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase
(Complex I). Am J Cancer Res. 2015 Jan 15;5(2):689-701. eCollection 2015. PubMed
PMID: 25973307; PubMed Central PMCID: PMC4396027.



Additional Information