WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125212

CAS#: 21087-98-9

Description: Koenimbine is a natural product isolated from Murraya koenigii.

Chemical Structure

CAS# 21087-98-9

Theoretical Analysis

MedKoo Cat#: 125212
Name: Koenimbine
CAS#: 21087-98-9
Chemical Formula: C19H19NO2
Exact Mass: 293.14
Molecular Weight: 293.370
Elemental Analysis: C, 77.79; H, 6.53; N, 4.77; O, 10.91

Price and Availability

Size Price Availability Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3650 2 Weeks
2g USD 5650 2 Weeks
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Synonym: NSC 127152; Koenimbin; Kenimbine

IUPAC/Chemical Name: 8-methoxy-3,3,5-trimethyl-3,11-dihydropyrano[3,2-a]carbazole


InChi Code: InChI=1S/C19H19NO2/c1-11-9-15-14-10-12(21-4)5-6-16(14)20-17(15)13-7-8-19(2,3)22-18(11)13/h5-10,20H,1-4H3

SMILES Code: CC1=CC2=C(C3=C1OC(C=C3)(C)C)NC4=C2C=C(C=C4)OC

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 293.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Astaneh M, Ghafouri-Fard S, Fazeli Z, Taherian-Esfahani Z, Dashti S,
Motevaseli E. Assessment of anti-cancer effects of koenimbine on colon cancer
cells. Hum Antibodies. 2020;28(3):185-190. doi: 10.3233/HAB-200405. PMID:

2: Uvarani C, Ramesh P, Ravichandran K, Mohan PS, Ponnuswamy MN. 8-Meth-
oxy-3,3,5-trimethyl-3,11-dihydro-pyrano[3,2-a]carbazole. Acta Crystallogr Sect E
Struct Rep Online. 2010 Jun 5;66(Pt 7):o1581. doi: 10.1107/S160053681002074X.
PMID: 21587821; PMCID: PMC3006796.

3: Hobani YH. The Role of Oxidative Stress in Koenimbine-Induced DNA Damage and
Heat Shock Protein Modulation in HepG2 Cells. Integr Cancer Ther. 2017
Dec;16(4):563-571. doi: 10.1177/1534735416678982. Epub 2016 Nov 22. PMID:
27879375; PMCID: PMC5739142.

4: Nalli Y, Khajuria V, Gupta S, Arora P, Riyaz-Ul-Hassan S, Ahmed Z, Ali A.
Four new carbazole alkaloids from Murraya koenigii that display anti-
inflammatory and anti-microbial activities. Org Biomol Chem. 2016 Mar
28;14(12):3322-32. doi: 10.1039/c6ob00267f. Erratum in: Org Biomol Chem. 2018
Mar 14;16(11):1994. PMID: 26947457.

5: Chatterjee D, Narzish F, Borade P, Singh IP. Simultaneous quantitation of
nine carbazole alkaloids from Murraya koenigii (L.) Spreng by
1H qNMR spectroscopy. Nat Prod Res. 2023 Jun 16:1-9. doi:
10.1080/14786419.2023.2219819. Epub ahead of print. PMID: 37322993.

6: Pakrashy S, Mandal PK, Dey SK, Choudhury SM, Alasmary FA, Almalki AS, Islam
MA, Dolai M. Design of a Structurally Novel Multipotent Drug Candidate by the
Scaffold Architecture Technique for ACE-II, NSP15, and Mpro Protein
Inhibition: Identification and Isolation of a Natural Product to Prevent the
Severity of Future Variants of Covid 19 and a Colorectal Anticancer Drug. ACS
Omega. 2022 Sep 10;7(37):33408-33422. doi: 10.1021/acsomega.2c04051. PMID:
36157758; PMCID: PMC9494648.

7: Sadwal S, Bharati S, Dar ZA, Kaur S. Chemopreventive potential of
hydroethanolic Murraya koenigii leaves extract against DMBA induced breast
carcinogenesis: In-silico and in-vivo study. J Ethnopharmacol. 2023 Sep 8;319(Pt
1):117124. doi: 10.1016/j.jep.2023.117124. Epub ahead of print. PMID: 37678421.