Lometrexol disodium

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205977

CAS#: 120408-07-3 (sodium)

Description: Lometrexol, also known as LY264618, is a folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate.

Chemical Structure

Lometrexol disodium
CAS# 120408-07-3 (sodium)

Theoretical Analysis

MedKoo Cat#: 205977
Name: Lometrexol disodium
CAS#: 120408-07-3 (sodium)
Chemical Formula: C21H23N5Na2O6
Exact Mass:
Molecular Weight: 487.42
Elemental Analysis: C, 51.75; H, 4.76; N, 14.37; Na, 9.43; O, 19.69

Size Price Shipping out time Quantity
5mg USD 190 Same day
10mg USD 350 Same day
25mg USD 550 Same day
50mg USD 750 Same day
100mg USD 1250 Same day
200mg USD 1950 Same day
500mg USD 3950 Same day
1g USD 6950 Same day
Inquire bulk and customized quantity

Pricing updated 2021-02-25. Prices are subject to change without notice.

Lometrexol disodium, purity > 98%, is in stock. The same day shipping out after order is received.

Related CAS #: 120408-07-3 (sodium)   106400-81-1 (free acid)   1435784-14-7 (hydrate)   124511-17-7 (camsylate)    

Synonym: LY 264618; LY-264618; LY264618; NSC722969; NSC-722969; NSC-722969. (6R)DDATHF; LMTX; DDATHF disodium; Lometrexol sodium; Lometrexol.

IUPAC/Chemical Name: Disodium (4-(2-((R)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl)benzoyl)-L-glutamate


InChi Code: InChI=1S/C21H25N5O6.2Na/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28;;/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30);;/q;2*+1/p-2/t12-,15+;;/m1../s1

SMILES Code: O=C(O[Na])[C@@H](NC(C1=CC=C(CC[C@@H](CN2)CC3=C2NC(N)=NC3=O)C=C1)=O)CCC(O[Na])=O

White to off-white solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, soluble in water.

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Preparing Stock Solutions

The following data is based on the product molecular weight 487.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Li T, Song L, Zhang Y, Han Y, Zhan Z, Xv Z, Li Y, Tang Y, Yang Y, Wang S, Li S, Zheng L, Li Y, Gao Y. Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma. J Cell Mol Med. 2020 Jun;24(12):6704-6715. doi: 10.1111/jcmm.15322. Epub 2020 May 11. PMID: 32391636; PMCID: PMC7299692.

2: Scaletti E, Jemth AS, Helleday T, Stenmark P. Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs. FEBS Lett. 2019 Jul;593(14):1863-1873. doi: 10.1002/1873-3468.13455. Epub 2019 Jun 10. PMID: 31127856.

3: Xu L, Wang L, Wang J, Zhu Z, Chang G, Guo Y, Tian X, Niu B. The effect of inhibiting glycinamide ribonucleotide formyl transferase on the development of neural tube in mice. Nutr Metab (Lond). 2016 Aug 23;13(1):56. doi: 10.1186/s12986-016-0114-x. PMID: 27555878; PMCID: PMC4994272.

4: Fekry B, Esmaeilniakooshkghazi A, Krupenko SA, Krupenko NI. Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner. PLoS One. 2016 Jan 19;11(1):e0146618. doi: 10.1371/journal.pone.0146618. PMID: 26783755; PMCID: PMC4718595.

5: Li B, Li H, Bai Y, Kirschner-Schwabe R, Yang JJ, Chen Y, Lu G, Tzoneva G, Ma X, Wu T, Li W, Lu H, Ding L, Liang H, Huang X, Yang M, Jin L, Kang H, Chen S, Du A, Shen S, Ding J, Chen H, Chen J, von Stackelberg A, Gu L, Zhang J, Ferrando A, Tang J, Wang S, Zhou BB. Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL. Nat Med. 2015 Jun;21(6):563-71. doi: 10.1038/nm.3840. Epub 2015 May 11. PMID: 25962120; PMCID: PMC4670083.

6: Paiardini A, Fiascarelli A, Rinaldo S, Daidone F, Giardina G, Koes DR, Parroni A, Montini G, Marani M, Paone A, McDermott LA, Contestabile R, Cutruzzolà F. Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase. ChemMedChem. 2015 Mar;10(3):490-7. doi: 10.1002/cmdc.201500028. Epub 2015 Feb 10. PMID: 25677305; PMCID: PMC5438088.

7: Tomsho JW, Moran RG, Coward JK. Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. Biochemistry. 2008 Aug 26;47(34):9040-50. doi: 10.1021/bi800406w. Epub 2008 Aug 2. PMID: 18672898; PMCID: PMC2805413.

8: Qi H, Ratnam M. Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. Cancer Res. 2006 Jun 1;66(11):5875-82. doi: 10.1158/0008-5472.CAN-05-4048. PMID: 16740727.

9: Tomsho JW, McGuire JJ, Coward JK. Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-gamma-glutamates: kinetics of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. Org Biomol Chem. 2005 Sep 21;3(18):3388-98. doi: 10.1039/b505907k. Epub 2005 Aug 15. Erratum in: Org Biomol Chem. 2005 Oct 21;3(20):3825. PMID: 16132101; PMCID: PMC1989673.

10: Cheng H, Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Design, synthesis, and biological evaluation of 10-methanesulfonyl- DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. Bioorg Med Chem. 2005 May 16;13(10):3577-85. doi: 10.1016/j.bmc.2004.12.004. PMID: 15848770.

11: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Oct;26(8):639-63. PMID: 15605126.

12: Dumez H, Reinhart WH, Guetens G, de Bruijn EA. Human red blood cells: rheological aspects, uptake, and release of cytotoxic drugs. Crit Rev Clin Lab Sci. 2004;41(2):159-88. doi: 10.1080/10408360490452031. PMID: 15270553.

13: Theti DS, Jackman AL. The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs. Clin Cancer Res. 2004 Feb 1;10(3):1080-9. doi: 10.1158/1078-0432.ccr-03-0157. PMID: 14871988.

14: Kamal MA, Christopherson RI. Accumulation of 5-phosphoribosyl-1-pyrophosphate in human CCRF-CEM leukaemia cells treated with antifolates. Int J Biochem Cell Biol. 2004 Mar;36(3):545-51. doi: 10.1016/j.biocel.2003.08.014. Erratum in: Int J Biochem Cell Biol. 2004 May;36(5):957. PMID: 14687931.

15: Bronder JL, Moran RG. A defect in the p53 response pathway induced by de novo purine synthesis inhibition. J Biol Chem. 2003 Dec 5;278(49):48861-71. doi: 10.1074/jbc.M304844200. Epub 2003 Sep 29. PMID: 14517211.

16: Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry. 2003 May 27;42(20):6043-56. doi: 10.1021/bi034219c. PMID: 12755606.

17: Purcell WT, Ettinger DS. Novel antifolate drugs. Curr Oncol Rep. 2003 Mar;5(2):114-25. doi: 10.1007/s11912-003-0098-3. PMID: 12583828.

18: Bronder JL, Moran RG. Antifolates targeting purine synthesis allow entry of tumor cells into S phase regardless of p53 function. Cancer Res. 2002 Sep 15;62(18):5236-41. PMID: 12234990.

19: Mauritz R, Peters GJ, Priest DG, Assaraf YG, Drori S, Kathmann I, Noordhuis P, Bunni MA, Rosowsky A, Schornagel JH, Pinedo HM, Jansen G. Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis. Biochem Pharmacol. 2002 Jan 15;63(2):105-15. doi: 10.1016/s0006-2952(01)00824-3. PMID: 11841783.

20: Rivory LP, Clarke SJ, Boyer M, Bishop JF. Highly sensitive analysis of the antifolate pemetrexed sodium, a new cancer agent, in human plasma and urine by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 2001 Dec 25;765(2):135-40. doi: 10.1016/s0378-4347(01)00406-6. PMID: 11767306.

Additional Information

 Related CAS#: 120408-07-3 (Lometrexol disodium); 106400-81-1 (Lometrexol)

Lometrexol free acid:
Chemical Formula: C21H25N5O6
Exact Mass: 443.1805
Molecular Weight: 443.4600
Elemental Analysis: C, 56.88; H, 5.68; N, 15.79; O, 21.65