Lometrexol disodium
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MedKoo CAT#: 205977

CAS#: 120408-07-3 (sodium)

Description: Lometrexol, also known as LY264618, is a folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 190 Same day
10mg USD 350 Same day
25mg USD 550 Same day
50mg USD 750 Same day
100mg USD 1250 Same day
200mg USD 1950 Same day
500mg USD 3950 Same day
1g USD 6950 Same day
Inquire bulk and customized quantity

Pricing updated 2021-01-20. Prices are subject to change without notice.

Lometrexol disodium, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205977
Name: Lometrexol disodium
CAS#: 120408-07-3 (sodium)
Chemical Formula: C21H23N5Na2O6
Exact Mass:
Molecular Weight: 487.42
Elemental Analysis: C, 51.75; H, 4.76; N, 14.37; Na, 9.43; O, 19.69


Related CAS #: 120408-07-3 (sodium)   106400-81-1 (free acid)   1435784-14-7 (hydrate)   124511-17-7 (camsylate)    

Synonym: LY 264618; LY-264618; LY264618; NSC722969; NSC-722969; NSC-722969. (6R)DDATHF; LMTX; DDATHF disodium; Lometrexol sodium; Lometrexol.

IUPAC/Chemical Name: Disodium (4-(2-((R)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl)benzoyl)-L-glutamate

InChi Key: SVJSWELRJWVPQD-KJWOGLQMSA-L

InChi Code: InChI=1S/C21H25N5O6.2Na/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28;;/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30);;/q;2*+1/p-2/t12-,15+;;/m1../s1

SMILES Code: O=C(O[Na])[C@@H](NC(C1=CC=C(CC[C@@H](CN2)CC3=C2NC(N)=NC3=O)C=C1)=O)CCC(O[Na])=O


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, soluble in water.

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

 Related CAS#: 120408-07-3 (Lometrexol disodium); 106400-81-1 (Lometrexol)

Lometrexol free acid:
Chemical Formula: C21H25N5O6
Exact Mass: 443.1805
Molecular Weight: 443.4600
Elemental Analysis: C, 56.88; H, 5.68; N, 15.79; O, 21.65
 
 
 


References

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