Lerisetron

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205975

CAS#: 143257-98-1

Description: Lerisetron is a serotonin type 3 (5-HT3) receptor antagonist with antiemetic activity. Lerisetron specifically binds to 5-HT3 receptors, located peripherally on vagus nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, which may result in suppression of chemotherapy-induced nausea and vomiting. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)


Chemical Structure

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Lerisetron
CAS# 143257-98-1

Theoretical Analysis

MedKoo Cat#: 205975
Name: Lerisetron
CAS#: 143257-98-1
Chemical Formula: C18H20N4
Exact Mass: 292.1688
Molecular Weight: 292.3782
Elemental Analysis: C, 73.94; H, 6.89; N, 19.16

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Synonym: Lerisetron; F0930RS.

IUPAC/Chemical Name: 1-benzyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole

InChi Key: PWWDCRQZITYKDV-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H20N4/c1-2-6-15(7-3-1)14-22-17-9-5-4-8-16(17)20-18(22)21-12-10-19-11-13-21/h1-9,19H,10-14H2

SMILES Code: C1(N2CCNCC2)=NC3=CC=CC=C3N1CC4=CC=CC=C4

Appearance: Solid powder

Purity: >98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 292.3782 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Lerisetron

10.0mg / Not available


Additional Information