KX02 (KX2-361)

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206196

CAS#: 897016-26-1

Description: KX02, also known as KX2-361, is a lipophilic, orally available inhibitor of both Src kinase activity and tubulin polymerization, with potential antineoplastic activity. Upon oral administration, src/tubulin inhibitor KX02 binds to and inhibits the activity of Src kinase. This inhibits both downstream signaling and the proliferation of Src kinase-expressing tumor cells. KX02 also binds to tubulin heterodimers and inhibits microtubule polymerization, thereby disrupting microtubule formation, mitosis, and further proliferation.


Chemical Structure

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KX02 (KX2-361)
CAS# 897016-26-1

Theoretical Analysis

MedKoo Cat#: 206196
Name: KX02 (KX2-361)
CAS#: 897016-26-1
Chemical Formula: C24H24FN3O2
Exact Mass: 405.1853
Molecular Weight: 405.4734
Elemental Analysis: C, 71.09; H, 5.97; F, 4.69; N, 10.36; O, 7.89

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Synonym: KX 2-361; KX2-361; KX-2-361; KX 2361; KX2361; KX-2361; KX 2361; KX 02; KX02; KX-02

IUPAC/Chemical Name: N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl)acetamide

InChi Key: CMKKPJNMYLOUCE-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H24FN3O2/c25-21-3-1-2-18(14-21)16-27-24(29)15-22-7-4-20(17-26-22)19-5-8-23(9-6-19)28-10-12-30-13-11-28/h1-9,14,17H,10-13,15-16H2,(H,27,29)

SMILES Code: O=C(NCC1=CC=CC(F)=C1)CC2=NC=C(C3=CC=C(N4CCOCC4)C=C3)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 405.4734 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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KX02 (KX2-361)

10.0mg / Not available


Additional Information