WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556336
Description: KWCN-41 is a selective and efficient inhibitor of RIPK1 kinase with an IC50 value of 88 nM. KWCN-41, specifically inhibiting cell necroptosis but not apoptosis, protects cell survival by blocking the necroptotic pathway, which inhibits the phosphorylation of essential proteins of the necroptosis. It also prevented the development of inflammation and reduced the level of inflammatory factors in mice. KWCN-41 is expected to be a lead compound for further studies in inflammatory diseases.
MedKoo Cat#: 556336
Chemical Formula: C18H17N3O2
Exact Mass: 307.1321
Molecular Weight: 307.353
Elemental Analysis: C, 70.34; H, 5.58; N, 13.67; O, 10.41
Synonym: KWCN-41; KWCN 41; KWCN41;
IUPAC/Chemical Name: (4-(1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl)(morpholino)methanone
InChi Key: SBSCPNOOKRZFKO-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H17N3O2/c22-18(21-8-10-23-11-9-21)14-5-3-13(4-6-14)16-12-15-2-1-7-19-17(15)20-16/h1-7,12H,8-11H2,(H,19,20)
SMILES Code: O=C(N1CCOCC1)C2=CC=C(C3=CC4=C(N3)N=CC=C4)C=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 307.353 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Cui N, Li S, Zhang Y, Yin F, Chen X, Luo Z, Wan S, Li X, Kong L, Wang X. Discovery of Sibiriline derivatives as novel receptor-interacting protein kinase 1 inhibitors. Eur J Med Chem. 2023 Mar 15;250:115190. doi: 10.1016/j.ejmech.2023.115190. Epub 2023 Feb 9. PMID: 36801518.