SBS probe
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MedKoo CAT#: 556326

CAS#: 291766-06-8

Description: SBS is a useful probe and tool molecule for detecting amyloid deposits in systemic amyloidosis in vitro and in vivo. SBS can be used for detecting amyloid fibrils in autopsy and biopsy samples from patients with localized amyloidosis, such as familial prion disease, and systemic amyloidosis, such as familial amyloidotic polyneuropathy, amyloid A (AA) amyloidosis, light chain (AL) amyloidosis, and dialysis-related amyloidosis. BSB showed reactions in all Congo red-pos. and immunoreactive regions of the samples examined in the study, and some amyloid fibrils in the tissues could be detected more precisely with BSB than with the other methods. In the mouse model of AA amyloidosis, injected BSB reacted with amyloid in all regions in the serial sections in which Congo red staining was pos. BSB showed a significant affinity for amyloid fibrils purified from familial amyloidotic polyneuropathy and dialysis-related amyloidosis samples and suppressed formation of transthyretin amyloid in vitro.

Chemical Structure

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SBS probe
CAS# 291766-06-8
Instruction

Theoretical Analysis

MedKoo Cat#: 556326
Name: SBS probe
CAS#: 291766-06-8
Chemical Formula: C24H17BrO6
Exact Mass: 480.02
Molecular Weight: 481.298
Elemental Analysis: C, 59.89; H, 3.56; Br, 16.60; O, 19.94

Price and Availability

Size Price Availability Quantity
10mg USD 550 2 Weeks
25mg USD 950 2 Weeks
100mg USD 1950 2 Weeks
500mg USD 2950 2 Weeks
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Synonym: SBS probe;

IUPAC/Chemical Name: Benzoic acid, 3,3′-[(2-bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis[6-hydroxy-

InChi Key: ZVECSLHUCRIBDY-WMWQKROPSA-N

InChi Code: InChI=1S/C24H17BrO6/c25-20-13-16(2-1-14-5-9-21(26)18(11-14)23(28)29)4-8-17(20)7-3-15-6-10-22(27)19(12-15)24(30)31/h1-13,26-27H,(H,28,29)(H,30,31)/b2-1+,7-3+

SMILES Code: BrC1=CC(/C=C/C2=CC(C(O)=O)=C(O)C=C2)=CC=C1/C=C/C3=CC(C(O)=O)=C(O)C=C3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 481.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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