WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206145
Description: DTP348 is an oral dual CAIX inhibitor/ radiosensitizer. DTP 348 is an oral dual drug with two mechanisms of action: (1). carbonic anhydrase IX inhibitor which acidifies the intracellular pH through the sulfamide components; (2). radio sensitizer of hypoxic cells through its 5-nitroimidazole moiety.
MedKoo Cat#: 206145
Chemical Formula: C6H11N5O4S
Exact Mass: 249.05317
Molecular Weight: 249.25
Elemental Analysis: C, 28.91; H, 4.45; N, 28.10; O, 25.68; S, 12.86
DTP348 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: DTP348; DTP 348; DTP-348.
IUPAC/Chemical Name: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethylsulfamide.
InChi Key: AVSMSXHPIYIKIJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C6H11N5O4S/c1-5-8-4-6(11(12)13)10(5)3-2-9-16(7,14)15/h4,9H,2-3H2,1H3,(H2,7,14,15)
SMILES Code: O=S(NCCN1C([N+]([O-])=O)=CN=C1C)(N)=O
The following data is based on the product molecular weight 249.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Rami, Marouan; Dubois, Ludwig; Parvathaneni, Nanda-Kumar; Alterio, Vincenzo; van Kuijk, Simon J. A.; Monti, Simona Maria; Lambin, Philippe; De Simone, Giuseppina; Supuran, Claudiu T.; Winum, Jean-Yves. Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates. Journal of Medicinal Chemistry (2013), 56(21), 8512-8520. |