WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206096
CAS#: 1190094-64-4
Description: CP-609754, also known as CP-609,754, LNK 754 and OSI 754, is a potent arnesyltransferase inhibitor with potential anticancer activity.
MedKoo Cat#: 206096
Name: CP-609754
CAS#: 1190094-64-4
Chemical Formula: C29H22ClN3O2
Exact Mass: 479.14005
Molecular Weight: 479.95688
Elemental Analysis: C, 72.57; H, 4.62; Cl, 7.39; N, 8.75; O, 6.67
CP-609754 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: CP-609754; CP609754; CP 609754; LNK 754; OSI 754.
IUPAC/Chemical Name: (R)-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one
InChi Key: JAHDAIPFBPPQHQ-GDLZYMKVSA-N
InChi Code: InChI=1S/C29H22ClN3O2/c1-4-19-6-5-7-20(14-19)24-16-28(34)33(3)26-13-10-22(15-25(24)26)29(35,27-17-31-18-32(27)2)21-8-11-23(30)12-9-21/h1,5-18,35H,2-3H3/t29-/m1/s1
SMILES Code: O=C1N(C)C2=C(C=C([C@](O)(C3=CC=C(Cl)C=C3)C4=CN=CN4C)C=C2)C(C5=CC=CC(C#C)=C5)=C1
The following data is based on the product molecular weight 479.95688 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Moulder SL, Mahany JJ, Lush R, Rocha-Lima C, Langevin M, Ferrante KJ, Bartkowski LM, Kajiji SM, Noe DA, Paillet S, Sullivan DM. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35. PubMed PMID: 15534083.