WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 205612
Description: RG7304, also known as R7304 or CK-127, is a MEK inhibitor currently in clinical trials.
MedKoo Cat#: 205612
Chemical Formula: C12H12N4O
Exact Mass: 228.1011
Molecular Weight: 228.255
Elemental Analysis: C, 63.15; H, 5.30; N, 24.55; O, 7.01
RG7304 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: CKI27; CK127; CK 127; RG7304; RG7304; RG 7304 R7304.
IUPAC/Chemical Name: (E)-5-(2-benzylidene-1-methylhydrazinyl)pyridazin-3(2H)-one
InChi Key: CTGDOGPKSFBVDA-RIYZIHGNSA-N
InChi Code: InChI=1S/C12H12N4O/c1-16(11-7-12(17)15-13-9-11)14-8-10-5-3-2-4-6-10/h2-9H,1H3,(H,15,17)/b14-8+
SMILES Code: CN(C(C=NN1)=CC1=O)/N=C/C2=CC=CC=C2
The following data is based on the product molecular weight 228.255 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Chiou GC, Xuan B, Yamasaki T, Okawara T. Anti-inflammation and
antifibroblastic actions of interleukin-1 blockers. J Ocul Pharmacol Ther. 1998
Aug;14(4):375-88. PubMed PMID: 9715441.
CKI 27 (RG7304) is a MEK inhibitor currently in clinical trials.