WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 205612
Description: RG7304, also known as R7304 or CK-127, is a MEK inhibitor currently in clinical trials.
MedKoo Cat#: 205612
Chemical Formula: C12H12N4O
Exact Mass: 228.1011
Molecular Weight: 228.255
Elemental Analysis: C, 63.15; H, 5.30; N, 24.55; O, 7.01
Synonym: CKI27; CK127; CK 127; RG7304; RG7304; RG 7304 R7304.
IUPAC/Chemical Name: (E)-5-(2-benzylidene-1-methylhydrazinyl)pyridazin-3(2H)-one
InChi Key: CTGDOGPKSFBVDA-RIYZIHGNSA-N
InChi Code: InChI=1S/C12H12N4O/c1-16(11-7-12(17)15-13-9-11)14-8-10-5-3-2-4-6-10/h2-9H,1H3,(H,15,17)/b14-8+
SMILES Code: CN(C(C=NN1)=CC1=O)/N=C/C2=CC=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 228.255 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Chiou GC, Xuan B, Yamasaki T, Okawara T. Anti-inflammation and
antifibroblastic actions of interleukin-1 blockers. J Ocul Pharmacol Ther. 1998
Aug;14(4):375-88. PubMed PMID: 9715441.
CKI 27 (RG7304) is a MEK inhibitor currently in clinical trials.