WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 200700

CAS#: 169590-42-5

Description: Celecoxib, also known as SC-58635 and YM-177, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in people two years or older.

Chemical Structure

CAS# 169590-42-5

Theoretical Analysis

MedKoo Cat#: 200700
Name: Celecoxib
CAS#: 169590-42-5
Chemical Formula: C17H14F3N3O2S
Exact Mass: 381.07588
Molecular Weight: 381.37
Elemental Analysis: C, 53.54; H, 3.70; F, 14.94; N, 11.02; O, 8.39; S, 8.41

Size Price Shipping out time Quantity
1g USD 150 Same day
5g USD 450 Same day
10g USD 750 Same day
20g USD 1250 Same day
100g USD 2150 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-27. Prices are subject to change without notice.

Celecoxib, purity > 98%, is in stock. The same day shipping after order received.

Synonym: SC-58635; SC 58635; SC58635; YM-177; YM 177; YM177. Celecoxib; brand name Celebrex; Xilebao.

IUPAC/Chemical Name: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide


InChi Code: InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)

SMILES Code: O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=C(C)C=C3)C=C1)(N)=O

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Certificate of Analysis:

Safety Data Sheet (SDS):

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 381.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Dinh TN, Onea AS, Jazirehi AR. Combination of celecoxib (Celebrex(®)) and CD19 CAR-redirected CTL immunotherapy for the treatment of B-cell non-Hodgkin's lymphomas. Am J Clin Exp Immunol. 2017 May 15;6(3):27-42. eCollection 2017. Review. PubMed PMID: 28804691; PubMed Central PMCID: PMC5545683.

2: Garner SE, Fidan D, Frankish RR, Judd M, Shea B, Towheed T, Tugwell P, Wells GA. WITHDRAWN: Celecoxib for rheumatoid arthritis. Cochrane Database Syst Rev. 2017 Jun 9;6:CD003831. doi: 10.1002/14651858.CD003831.pub2. Review. PubMed PMID: 28598564.

3: Fidahic M, Jelicic Kadic A, Radic M, Puljak L. Celecoxib for rheumatoid arthritis. Cochrane Database Syst Rev. 2017 Jun 9;6:CD012095. doi: 10.1002/14651858.CD012095.pub2. Review. PubMed PMID: 28597983.

4: Puljak L, Marin A, Vrdoljak D, Markotic F, Utrobicic A, Tugwell P. Celecoxib for osteoarthritis. Cochrane Database Syst Rev. 2017 May 22;5:CD009865. doi: 10.1002/14651858.CD009865.pub2. Review. PubMed PMID: 28530031.

5: Dean L. Celecoxib Therapy and CYP2C9 Genotype. 2016 Aug 18. In: Pratt V, McLeod H, Dean L, Malheiro A, Rubinstein W, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-. Available from http://www.ncbi.nlm.nih.gov/books/NBK379478/ PubMed PMID: 28520369.

6: Celecoxib safety revisited. Med Lett Drugs Ther. 2016 Dec 19;58(1510):159. Review. PubMed PMID: 27960193.

7: Marini S, De Berardis D, Vellante F, Santacroce R, Orsolini L, Valchera A, Girinelli G, Carano A, Fornaro M, Gambi F, Martinotti G, Di Giannantonio M. Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials. Mediators Inflamm. 2016;2016:3476240. doi: 10.1155/2016/3476240. Epub 2016 Jul 25. Review. PubMed PMID: 27524864; PubMed Central PMCID: PMC4976163.

8: Xu C, Gu K, Yasen Y, Hou Y. Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore). 2016 May;95(20):e3585. doi: 10.1097/MD.0000000000003585. Review. PubMed PMID: 27196460; PubMed Central PMCID: PMC4902402.

9: Celecoxib With or Without Zoledronic Acid for Hormone-Naïve Prostate Cancer: Survival Results From STAMPEDE (NCT00268476). Clin Adv Hematol Oncol. 2016 Apr;14(4 Suppl 5):11-3. Review. PubMed PMID: 27167844.

10: Papageorgiou N, Zacharia E, Briasoulis A, Charakida M, Tousoulis D. Celecoxib for the treatment of atherosclerosis. Expert Opin Investig Drugs. 2016;25(5):619-33. doi: 10.1517/13543784.2016.1161756. Epub 2016 Mar 21. Review. PubMed PMID: 26940257.

11: Khan JS, Margarido C, Devereaux PJ, Clarke H, McLellan A, Choi S. Preoperative celecoxib in noncardiac surgery: A systematic review and meta-analysis of randomised controlled trials. Eur J Anaesthesiol. 2016 Mar;33(3):204-14. doi: 10.1097/EJA.0000000000000346. Review. PubMed PMID: 26760402.

12: Hou LC, Huang F, Xu HB. Does celecoxib improve the efficacy of chemotherapy for advanced non-small cell lung cancer? Br J Clin Pharmacol. 2016 Jan;81(1):23-32. doi: 10.1111/bcp.12757. Epub 2015 Nov 2. Review. PubMed PMID: 26331772; PubMed Central PMCID: PMC4693572.

13: Chen J, Shen P, Zhang XC, Zhao MD, Zhang XG, Yang L. Efficacy and safety profile of celecoxib for treating advanced cancers: a meta-analysis of 11 randomized clinical trials. Clin Ther. 2014 Aug 1;36(8):1253-63. doi: 10.1016/j.clinthera.2014.06.015. Epub 2014 Jul 10. Review. PubMed PMID: 25016505.

14: Faridhosseini F, Sadeghi R, Farid L, Pourgholami M. Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta-analysis of randomized placebo-controlled trials. Hum Psychopharmacol. 2014 May;29(3):216-23. doi: 10.1002/hup.2401. Epub 2014 Mar 16. Review. PubMed PMID: 24911574.

15: Frolov RV, Singh S. Celecoxib and ion channels: a story of unexpected discoveries. Eur J Pharmacol. 2014 May 5;730:61-71. doi: 10.1016/j.ejphar.2014.02.032. Epub 2014 Mar 11. Review. PubMed PMID: 24630832.

16: Scheinfeld N. Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine. Dermatol Online J. 2013 Nov 15;19(11):20616. Review. PubMed PMID: 24314785.

17: Derry S, Moore RA. Single dose oral celecoxib for acute postoperative pain in adults. Cochrane Database Syst Rev. 2013 Oct 22;(10):CD004233. doi: 10.1002/14651858.CD004233.pub4. Review. PubMed PMID: 24150982.

18: Kumar V, Kaur K, Gupta GK, Gupta AK, Kumar S. Developments in synthesis of the anti-inflammatory drug, celecoxib: a review. Recent Pat Inflamm Allergy Drug Discov. 2013 May;7(2):124-34. Review. PubMed PMID: 23565678.

19: Huelin R, Pokora T, Foster TS, Mould JF. Economic outcomes for celecoxib: a systematic review of pharmacoeconomic studies. Expert Rev Pharmacoecon Outcomes Res. 2012 Aug;12(4):505-23. doi: 10.1586/erp.12.36. Review. PubMed PMID: 22971036.

20: Derry S, Moore RA. Single dose oral celecoxib for acute postoperative pain in adults. Cochrane Database Syst Rev. 2012 Mar 14;(3):CD004233. doi: 10.1002/14651858.CD004233.pub3. Review. Update in: Cochrane Database Syst Rev. 2013;(10):CD004233. PubMed PMID: 22419293; PubMed Central PMCID: PMC4161494.