WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 130011
CAS#: 208706-12-1
Description: L-054264 is an SSTR2 agonist that has been shown to reduce the expression of fear in rats, but not fear acquisition itself.
MedKoo Cat#: 130011
Name: L-054264
CAS#: 208706-12-1
Chemical Formula: C33H41N5O2
Exact Mass: 539.326
Molecular Weight: 539.72
Elemental Analysis: C, 73.44; H, 7.66; N, 12.98; O, 5.93
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Synonym: L-054264; L054264; L 054264; L-054,264
IUPAC/Chemical Name: N-((R)-3-(1H-indol-3-yl)-1-(methyl((1R,3S)-3-(methylamino)cyclohexyl)amino)-1-oxopropan-2-yl)spiro[indene-1,4'-piperidine]-1'-carboxamide
InChi Key: JHPJTVLDEHDVOR-LUXHBGHRSA-N
InChi Code: InChI=1S/C33H41N5O2/c1-34-25-9-7-10-26(21-25)37(2)31(39)30(20-24-22-35-29-13-6-4-11-27(24)29)36-32(40)38-18-16-33(17-19-38)15-14-23-8-3-5-12-28(23)33/h3-6,8,11-15,22,25-26,30,34-35H,7,9-10,16-21H2,1-2H3,(H,36,40)/t25-,26+,30+/m0/s1
SMILES Code: O=C(N1CCC2(CC1)C=CC3=C2C=CC=C3)N[C@H](CC4=CNC5=C4C=CC=C5)C(N([C@H]6C[C@@H](NC)CCC6)C)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 539.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Kahl E, Fendt M. Injections of the somatostatin receptor type 2 agonist L-054,264 into the amygdala block expression but not acquisition of conditioned fear in rats. Behav Brain Res. 2014 May 15;265:49-52. doi: 10.1016/j.bbr.2014.02.011. Epub 2014 Feb 15. PMID: 24548855.
2. Yang L, Guo L, Pasternak A, Mosley R, Rohrer S, Birzin E, Foor F, Cheng K, Schaeffer J, Patchett AA. Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J Med Chem. 1998 Jun 18;41(13):2175-9. doi: 10.1021/jm980194h. PMID: 9632348.
3. Vuong HE, Hardi CN, Barnes S, Brecha NC. Parallel Inhibition of Dopamine Amacrine Cells and Intrinsically Photosensitive Retinal Ganglion Cells in a Non-Image-Forming Visual Circuit of the Mouse Retina. J Neurosci. 2015 Dec 2;35(48):15955-70. doi: 10.1523/JNEUROSCI.3382-15.2015. PMID: 26631476; PMCID: PMC4666919.
