L-054264

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130011

CAS#: 208706-12-1

Description: L-054264 is an SSTR2 agonist that has been shown to reduce the expression of fear in rats, but not fear acquisition itself.


Chemical Structure

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L-054264
CAS# 208706-12-1

Theoretical Analysis

MedKoo Cat#: 130011
Name: L-054264
CAS#: 208706-12-1
Chemical Formula: C33H41N5O2
Exact Mass: 539.33
Molecular Weight: 539.720
Elemental Analysis: C, 73.44; H, 7.66; N, 12.98; O, 5.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L-054264; L054264; L 054264; L-054,264

IUPAC/Chemical Name: N-((R)-3-(1H-indol-3-yl)-1-(methyl((1R,3S)-3-(methylamino)cyclohexyl)amino)-1-oxopropan-2-yl)spiro[indene-1,4'-piperidine]-1'-carboxamide

InChi Key: JHPJTVLDEHDVOR-LUXHBGHRSA-N

InChi Code: InChI=1S/C33H41N5O2/c1-34-25-9-7-10-26(21-25)37(2)31(39)30(20-24-22-35-29-13-6-4-11-27(24)29)36-32(40)38-18-16-33(17-19-38)15-14-23-8-3-5-12-28(23)33/h3-6,8,11-15,22,25-26,30,34-35H,7,9-10,16-21H2,1-2H3,(H,36,40)/t25-,26+,30+/m0/s1

SMILES Code: O=C(N1CCC2(CC1)C=CC3=C2C=CC=C3)N[C@H](CC4=CNC5=C4C=CC=C5)C(N([C@H]6C[C@@H](NC)CCC6)C)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 539.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Kahl E, Fendt M. Injections of the somatostatin receptor type 2 agonist L-054,264 into the amygdala block expression but not acquisition of conditioned fear in rats. Behav Brain Res. 2014 May 15;265:49-52. doi: 10.1016/j.bbr.2014.02.011. Epub 2014 Feb 15. PMID: 24548855.

2. Yang L, Guo L, Pasternak A, Mosley R, Rohrer S, Birzin E, Foor F, Cheng K, Schaeffer J, Patchett AA. Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J Med Chem. 1998 Jun 18;41(13):2175-9. doi: 10.1021/jm980194h. PMID: 9632348.

3. Vuong HE, Hardi CN, Barnes S, Brecha NC. Parallel Inhibition of Dopamine Amacrine Cells and Intrinsically Photosensitive Retinal Ganglion Cells in a Non-Image-Forming Visual Circuit of the Mouse Retina. J Neurosci. 2015 Dec 2;35(48):15955-70. doi: 10.1523/JNEUROSCI.3382-15.2015. PMID: 26631476; PMCID: PMC4666919.