WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205831

CAS#: 467421-06-3

Description: CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6).

Chemical Structure

CAS# 467421-06-3

Theoretical Analysis

MedKoo Cat#: 205831
Name: CC-1088
CAS#: 467421-06-3
Chemical Formula: C17H14N2O3
Exact Mass: 294.1004
Molecular Weight: 294.31
Elemental Analysis: C, 69.38; H, 4.79; N, 9.52; O, 16.31

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Synonym: CC1088; CC 1088; CC-1088.

IUPAC/Chemical Name: 3-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanamide


InChi Code: InChI=1S/C17H14N2O3/c18-15(20)10-14(11-6-2-1-3-7-11)19-16(21)12-8-4-5-9-13(12)17(19)22/h1-9,14H,10H2,(H2,18,20)

SMILES Code: O=C(C1=CC=CC=C12)N(C(C3=CC=CC=C3)CC(N)=O)C2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 294.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Dredge K. CC-1088 Celgene. Curr Opin Investig Drugs. 2005 May;6(5):513-7.
Review. PubMed PMID: 15912966.

2: Molostvov G, Morris A, Rose P, Basu S, Muller G. The effects of selective
cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and
apoptosis in myeloma and endothelial cell co-cultures. Br J Haematol. 2004
Feb;124(3):366-75. PubMed PMID: 14717786.


10.0mg / Not available

Additional Information