WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 205831
Description: CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6).
MedKoo Cat#: 205831
Chemical Formula: C17H14N2O3
Exact Mass: 294.1004
Molecular Weight: 294.31
Elemental Analysis: C, 69.38; H, 4.79; N, 9.52; O, 16.31
CC-1088, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: CC1088; CC 1088; CC-1088.
IUPAC/Chemical Name: 3-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanamide
InChi Key: ZJZWDDCSXLSDJG-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H14N2O3/c18-15(20)10-14(11-6-2-1-3-7-11)19-16(21)12-8-4-5-9-13(12)17(19)22/h1-9,14H,10H2,(H2,18,20)
SMILES Code: O=C(C1=CC=CC=C12)N(C(C3=CC=CC=C3)CC(N)=O)C2=O
The following data is based on the product molecular weight 294.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Dredge K. CC-1088 Celgene. Curr Opin Investig Drugs. 2005 May;6(5):513-7.
Review. PubMed PMID: 15912966.
2: Molostvov G, Morris A, Rose P, Basu S, Muller G. The effects of selective
cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and
apoptosis in myeloma and endothelial cell co-cultures. Br J Haematol. 2004
Feb;124(3):366-75. PubMed PMID: 14717786.