CC-115
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MedKoo CAT#: 205829

CAS#: 1228013-15-7 (free base)

Description: CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a member of the PI3K-related kinase subfamily of protein kinases, is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway.


Chemical Structure

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CC-115
CAS# 1228013-15-7 (free base)

Theoretical Analysis

MedKoo Cat#: 205829
Name: CC-115
CAS#: 1228013-15-7 (free base)
Chemical Formula: C16H16N8O
Exact Mass: 336.14471
Molecular Weight: 336.14
Elemental Analysis: C, 57.13; H, 4.79; N, 33.31; O, 4.76

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 750 Same day
200mg USD 1250 Same day
500mg USD 1950 Same day
1g USD 3250 2 Weeks
2g USD 4250 2 Weeks
5g USD 6750 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-26. Prices are subject to change without notice.

CC-115, purity > 98%, is in stock. The same day shipping out after order is received.

Related CAS #: 1228013-15-7 (free base)   1300118-55-1 (HCl)    

Synonym: CC115 ; CC-115; CC 115.

IUPAC/Chemical Name: 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

InChi Key: GMYLVKUGJMYTFB-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H16N8O/c1-3-24-13(25)7-18-15-16(24)22-12(6-17-15)10-4-5-11(21-9(10)2)14-19-8-20-23-14/h4-6,8H,3,7H2,1-2H3,(H,17,18)(H,19,20,23)

SMILES Code: O=C1CNC2=NC=C(C3=CC=C(C4=NC=NN4)N=C3C)N=C2N1CC

Appearance:
Red Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 336.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Thijssen R, Ter Burg J, Garrick B, van Bochove GG, Brown JR, Fernandes SM, Rodríguez MS, Michot JM, Hallek M, Eichhorst B, Reinhardt HC, Bendell J, Derks IA, van Kampen RJ, Hege K, Kersten MJ, Trowe T, Filvaroff EH, Eldering E, Kater AP. Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. Blood. 2016 Jul 28;128(4):574-83. doi: 10.1182/blood-2016-02-700328. Epub 2016 May 27. PubMed PMID: 27235137.

2: Mortensen DS, Perrin-Ninkovic SM, Shevlin G, Elsner J, Zhao J, Whitefield B, Tehrani L, Sapienza J, Riggs JR, Parnes JS, Papa P, Packard G, Lee BG, Harris R, Correa M, Bahmanyar S, Richardson SJ, Peng SX, Leisten J, Khambatta G, Hickman M, Gamez JC, Bisonette RR, Apuy J, Cathers BE, Canan SS, Moghaddam MF, Raymon HK, Worland P, Narla RK, Fultz KE, Sankar S. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23;58(14):5599-608. doi: 10.1021/acs.jmedchem.5b00627. Epub 2015 Jul 8. PubMed PMID: 26102506.

3: Saiz C, Wipf P, Manta E, Mahler G. Reversible thiazolidine exchange: a new reaction suitable for dynamic combinatorial chemistry. Org Lett. 2009 Aug 6;11(15):3170-3. doi: 10.1021/ol901104a. Erratum in: Org Lett. 2010 Jul 16;12(14):3284. PubMed PMID: 19585999; PubMed Central PMCID: PMC2736333.

4: Warheit DB, Hartsky MA, McHugh TA, Kellar KA. Biopersistence of inhaled organic and inorganic fibers in the lungs of rats. Environ Health Perspect. 1994 Oct;102 Suppl 5:151-7. PubMed PMID: 7882921; PubMed Central PMCID: PMC1567301.



Additional Information

Related CAS#
CAS#1228013-15-7 (CC-115 free base);
CAS#1300118-55-1 (CC-115 .xHCl salt)