CA77.1
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MedKoo CAT#: 122929

CAS#: 2412270-22-3

Description: CA77.1 is an activator of chaperone-mediated autophagy (CMA). CA77.1 activates chaperone-mediated autophagy (CMA) by increasing the expression of the lysosomal receptor for this pathway, LAMP2A, in lysosomes. CA77.1 is a derivative of AR7. CA77.1 may help to degrade toxic pathogenic protein products such as tau proteins and has potential applications in the treatment of Alzheimer's disease.

Chemical Structure

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CA77.1
CAS# 2412270-22-3
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 122929
Name: CA77.1
CAS#: 2412270-22-3
Chemical Formula: C16H12ClN3O
Exact Mass: 297.07
Molecular Weight: 297.740
Elemental Analysis: C, 64.54; H, 4.06; Cl, 11.91; N, 14.11; O, 5.37

Price and Availability

Size Price Availability Quantity
25mg USD 150 Ready to Ship
50mg USD 250 Ready to Ship
100mg USD 450 Ready to Ship
200mg USD 750 Ready to Ship
500mg USD 1450 Ready to Ship
1g USD 2250 Ready to Ship
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Synonym: SCHEMBL21793861; DTXSID701336851; s6395; CA77.1;

IUPAC/Chemical Name: N-(4-(6-chloroquinoxalin-2-yl)phenyl)acetamide

InChi Key: ZQXMPDVGBWOTBY-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12ClN3O/c1-10(21)19-13-5-2-11(3-6-13)16-9-18-15-8-12(17)4-7-14(15)20-16/h2-9H,1H3,(H,19,21)

SMILES Code: O=C(NC1=CC=C(C=C1)C2=NC3=CC=C(Cl)C=C3N=C2)C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: CA77.1 can increase the expression of the lysosomal receptor LAMP2A in lysosomes. CA77.1 improves behavior and neuropathology in a mouse model with systemic and neuronal-specific CMA blockage.
In vitro activity: To be determined
In vivo activity: The chemical enhancement of CMA ameliorates pathology in two different Alzheimer's disease experimental mouse models. CM77.1 activates CMA. This study concludes that functional CMA is essential for neuronal proteostasis through the maintenance of a subset of the proteome with a higher risk of misfolding than the general proteome. Reference: Cell. 2021 May 13;184(10):2696-2714.e25. https://pubmed.ncbi.nlm.nih.gov/33891876/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.0 16.79

Preparing Stock Solutions

The following data is based on the product molecular weight 297.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184(10):2696-2714.e25. doi: 10.1016/j.cell.2021.03.048. Epub 2021 Apr 22. PMID: 33891876; PMCID: PMC8152331.
In vitro protocol: To be determined
In vivo protocol: 1. Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184(10):2696-2714.e25. doi: 10.1016/j.cell.2021.03.048. Epub 2021 Apr 22. PMID: 33891876; PMCID: PMC8152331.

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1. Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184(10):2696-2714.e25. doi: 10.1016/j.cell.2021.03.048. Epub 2021 Apr 22. PMID: 33891876; PMCID: PMC8152331.