WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556204

CAS#: 693288-97-0

Description: CPPHA is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) that potentiates human and rat mGluR5 activation by glutamate, 3,5-DHPG and quisqualate.

Chemical Structure

CAS# 693288-97-0

Theoretical Analysis

MedKoo Cat#: 556204
CAS#: 693288-97-0
Chemical Formula: C22H15ClN2O4
Exact Mass: 406.07
Molecular Weight: 406.822
Elemental Analysis: C, 64.95; H, 3.72; Cl, 8.71; N, 6.89; O, 15.73

Price and Availability

Size Price Availability Quantity
100mg USD 950 2 Weeks
200mg USD 1450 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3450 2 Weeks
2g USD 5450 2 Weeks
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Synonym: CPPHA

IUPAC/Chemical Name: N-[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxy-benzamide


InChi Code: InChI=1S/C22H15ClN2O4/c23-14-9-10-18(24-20(27)17-7-3-4-8-19(17)26)13(11-14)12-25-21(28)15-5-1-2-6-16(15)22(25)29/h1-11,26H,12H2,(H,24,27)


Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 406.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li S, Rizvi MH, Lynch BB, Tracy JB, Ford E. Flexible Cyclic- Poly(phthalaldehyde)/Poly(ε-caprolactone) Blend Fibers with Fast Daylight- Triggered Transience. Macromol Rapid Commun. 2021 Apr;42(7):e2000657. doi: 10.1002/marc.202000657. Epub 2020 Dec 28. PMID: 33368746.

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7: Noetzel MJ, Gregory KJ, Vinson PN, Manka JT, Stauffer SR, Lindsley CW, Niswender CM, Xiang Z, Conn PJ. A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling. Mol Pharmacol. 2013 Apr;83(4):835-47. doi: 10.1124/mol.112.082891. Epub 2013 Jan 24. Erratum in: Mol Pharmacol. 2013 Oct;84(4):654. PMID: 23348500; PMCID: PMC3608436.

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9: Hammond AS, Rodriguez AL, Townsend SD, Niswender CM, Gregory KJ, Lindsley CW, Conn PJ. Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chem Neurosci. 2010 Oct 20;1(10):702-716. doi: 10.1021/cn100051m. Epub 2010 Aug 19. PMID: 20981342; PMCID: PMC2957851.

10: Bradley SJ, Watson JM, Challiss RA. Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor. Mol Pharmacol. 2009 Dec;76(6):1302-13. doi: 10.1124/mol.109.059170. Epub 2009 Sep 8. PMID: 19737913; PMCID: PMC2784724.

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12: Chen Y, Goudet C, Pin JP, Conn PJ. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H- isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Mol Pharmacol. 2008 Mar;73(3):909-18. doi: 10.1124/mol.107.040097. Epub 2007 Dec 4. PMID: 18056795.

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