BMS-641988

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 200531

CAS#: 573738-99-5

Description: BMS-641988 is a nonsteroidal androgen receptor (AR) antagonist with anti-androgenic and potential antineoplastic activities. AR antagonist BMS-641988 binds to ARs in target tissues and prevents AR activation, which may result in the inhibition of AR-mediated transcriptional activity and tumor cell death in susceptible tumor cell populations. Global gene expression analysis has shown that exposure to this agent may result in a phenotype that is closer to a castration phenotype than is achievable with other antiandrogens such as bicalutamide.


Chemical Structure

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BMS-641988
CAS# 573738-99-5

Theoretical Analysis

MedKoo Cat#: 200531
Name: BMS-641988
CAS#: 573738-99-5
Chemical Formula: C20H20F3N3O5S
Exact Mass: 471.10758
Molecular Weight: 471.45
Elemental Analysis: C, 50.95; H, 4.28; F, 12.09; N, 8.91; O, 16.97; S, 6.80

Size Price Shipping out time Quantity
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Pricing updated 2021-02-26. Prices are subject to change without notice.

BMS-641988, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: BMS641988; BMS 641988; BMS-641988; Ethanesulfonamide.

IUPAC/Chemical Name: N-((3aR,4R,5R,7R,7aS)-2-(4-cyano-3-(trifluoromethyl)phenyl)-4,7-dimethyl-1,3-dioxooctahydro-1H-4,7-epoxyisoindol-5-yl)ethanesulfonamide.

InChi Key: HYNANJUKEMCYEQ-HIGHGGLBSA-N

InChi Code: InChI=1S/C20H20F3N3O5S/c1-4-32(29,30)25-13-8-18(2)14-15(19(13,3)31-18)17(28)26(16(14)27)11-6-5-10(9-24)12(7-11)20(21,22)23/h5-7,13-15,25H,4,8H2,1-3H3/t13-,14-,15+,18-,19+/m1/s1

SMILES Code: CCS(=O)(N[C@H](C[C@]1(C)[C@@]23[H])[C@@](O1)(C)[C@]3([H])C(N(C4=CC=C(C#N)C(C(F)(F)F)=C4)C2=O)=O)=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 471.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Attar RM, Jure-Kunkel M, Balog A, Cvijic ME, Dell-John J, Rizzo CA, Schweizer L, Spires TE, Platero JS, Obermeier M, Shan W, Salvati ME, Foster WR, Dinchuk J, Chen SJ, Vite G, Kramer R, Gottardis MM. Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signaling for the treatment of prostate cancer. Cancer Res. 2009 Aug 15;69(16):6522-30. Epub 2009 Aug 4. PubMed PMID: 19654297.



Additional Information