XZ-259

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130179

CAS#: N/A

Description: XZ-259, a strand transfer inhibitor of HIV-1 (HIV-1 integrase inhibitor), was vital in exploring the role of drug resistance mutations (G118R, Q148K) on the viral enzyme integrase (IN) inhibitor selectivity. Unlike raltegravir and elvitegravir, current agents for HIV treatment, XZ-259 was able to successfully inhibit the activity of integrases with the Q148K mutation, demonstrating the potential of XZ-259 as a treatment for HIV-1.


Chemical Structure

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XZ-259
CAS# N/A

Theoretical Analysis

MedKoo Cat#: 130179
Name: XZ-259
CAS#: N/A
Chemical Formula: C17H16ClFN2O5S
Exact Mass: 414.05
Molecular Weight: 414.832
Elemental Analysis: C, 49.22; H, 3.89; Cl, 8.55; F, 4.58; N, 6.75; O, 19.28; S, 7.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: XZ-259; XZ259; XZ 259

IUPAC/Chemical Name: 2-(3-chloro-4-fluorobenzyl)-6,7-dihydroxy-N,N-dimethyl-1-oxoisoindoline-4-sulfonamide

InChi Key: AUHJAAAKTCEGOJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H16ClFN2O5S/c1-20(2)27(25,26)14-6-13(22)16(23)15-10(14)8-21(17(15)24)7-9-3-4-12(19)11(18)5-9/h3-6,22-23H,7-8H2,1-2H3

SMILES Code: OC1=C(C2=C(C(S(=O)(N(C)C)=O)=C1)CN(C2=O)CC3=CC(Cl)=C(C=C3)F)O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 414.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Shadrina OA, Zatsepin TS, Agapkina YY, Isaguliants MG, Gottikh MB. Influence of Drug Resistance Mutations on the Activity of HIV-1 Subtypes A and B Integrases: a Comparative Study. Acta Naturae. 2015 Jan-Mar;7(1):78-86. PMID: 25927004; PMCID: PMC4410398.

2. Métifiot M, Maddali K, Johnson BC, Hare S, Smith SJ, Zhao XZ, Marchand C, Burke TR Jr, Hughes SH, Cherepanov P, Pommier Y. Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase. ACS Chem Biol. 2013 Jan 18;8(1):209-17. doi: 10.1021/cb300471n. Epub 2012 Dec 24. PMID: 23075516; PMCID: PMC3548936.