WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130176

CAS#: 904444-86-6

Description: HBX28364 is an inactive compound and serves as a negative control for HBX19818. The inactivity of the compound is a result of the lack of the basic alkyl amine side chain in HBX28364 as compared to HBX19818.

Chemical Structure

CAS# 904444-86-6

Theoretical Analysis

MedKoo Cat#: 130176
Name: HBX28364
CAS#: 904444-86-6
Chemical Formula: C22H20Cl2N2O
Exact Mass: 398.10
Molecular Weight: 399.320
Elemental Analysis: C, 66.17; H, 5.05; Cl, 17.76; N, 7.02; O, 4.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: HBX28364; HBX-28364; HBX 28364; HBX 28,364

IUPAC/Chemical Name: 9-chloro-N-(4-chlorophenethyl)-5,6,7,8-tetrahydroacridine-3-carboxamide


InChi Code: InChI=1S/C22H20Cl2N2O/c23-16-8-5-14(6-9-16)11-12-25-22(27)15-7-10-18-20(13-15)26-19-4-2-1-3-17(19)21(18)24/h5-10,13H,1-4,11-12H2,(H,25,27)


Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: HBX19818 is USP7 inhibitor for the exploration of the role of USP7 in endometrial stroma decidualization, a cause of failed pregnancies.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 399.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Reverdy C, Conrath S, Lopez R, Planquette C, Atmanene C, Collura V, Harpon J, Battaglia V, Vivat V, Sippl W, Colland F. Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme. Chem Biol. 2012 Apr 20;19(4):467-77. doi: 10.1016/j.chembiol.2012.02.007. PMID: 22520753.

2. Wu HQ, Baker D, Ovaa H. Small molecules that target the ubiquitin system. Biochem Soc Trans. 2020 Apr 29;48(2):479-497. doi: 10.1042/BST20190535. PMID: 32196552; PMCID: PMC7200645.

3. Cremer A, Stegmaier K. Targeting DUBs to degrade oncogenic proteins. Br J Cancer. 2020 Apr;122(8):1121-1123. doi: 10.1038/s41416-020-0728-7. Epub 2020 Feb 4. PMID: 32015509; PMCID: PMC7156467.

4. Gao Y, Wang Y, Zhou C, Kong S, Lu J, Wang H, Yang J. Ubiquitin-specific protease 7 (USP7) is essential for endometrial stromal cell decidualization in mice. Dev Growth Differ. 2019 Feb;61(2):176-185. doi: 10.1111/dgd.12594. Epub 2019 Jan 9. PMID: 30628051.