WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 122724

CAS#: 1815600-11-3

Description: T1742, also known as 4E 1RCat, is an autophagy Inhibitor by disrupting the Protein−Protein Interactions Involving Autophagy-Related 5. T1742 blocked the ATG5−ATG16L1 and ATG5−TECAIR interactions in the in vitro binding assay (IC50 = 1−2 μM) and also exhibited autophagy inhibition in cellular assays.

Chemical Structure

CAS# 1815600-11-3

Theoretical Analysis

MedKoo Cat#: 122724
Name: T1742
CAS#: 1815600-11-3
Chemical Formula: C28H18N2O6
Exact Mass: 478.12
Molecular Weight: 478.460
Elemental Analysis: C, 70.29; H, 3.79; N, 5.86; O, 20.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: T1742; T-1742; T 1742; 4E 1RCat;

IUPAC/Chemical Name: (E)-4-(3-((5-(4-nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid


InChi Code: InChI=1S/C28H18N2O6/c31-27-21(16-24-14-15-26(36-24)19-6-12-23(13-7-19)30(34)35)17-25(18-4-2-1-3-5-18)29(27)22-10-8-20(9-11-22)28(32)33/h1-17H,(H,32,33)/b21-16+

SMILES Code: O=C1N(C2=CC=C(C(O)=O)C=C2)C(C3=CC=CC=C3)=C/C1=C\C(O4)=CC=C4C5=CC=C([N+]([O-])=O)C=C5

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 478.460000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Xiang H, Liu R, Zhang X, An R, Zhou M, Tan C, Li Q, Su M, Guo C, Zhou L, Li Y, Wang R. Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein-Protein Interactions Involving Autophagy-Related 5. J Med Chem. 2023 Feb 7. doi: 10.1021/acs.jmedchem.2c01233. Epub ahead of print. PMID: 36749313.