AS101

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205817

CAS#: 106566-58-9

Description: AS101, also known as Ossirene, is a synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immuno-modulating, antiviral, and hair growth-promoting activities. Ammonium trichlorotellurate may inhibit the inflammatory cytokine interleukin-10 (IL-10) and may induce hematopoietic cells to express interleukin-2 (IL-2), IL-2 receptors, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, tumor necrosis factor (TNF) and interferons (INFs). This agent is also a potent inducer of IL-1 and IL-6. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced myelosuppression. In addition, this agent exhibits hair growth-promoting activity by inducing anagen production and inhibiting catagen production, resulting in the promotion of follicular keratinocyte proliferation and interference with follicular keratinocyte terminal differentiation, respectively. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced alopecia.

Chemical Structure

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AS101
CAS# 106566-58-9
Instruction

Theoretical Analysis

MedKoo Cat#: 205817
Name: AS101
CAS#: 106566-58-9
Chemical Formula: C2H8Cl3NO2Te
Exact Mass: 0.00
Molecular Weight: 312.049
Elemental Analysis: C, 7.70; H, 2.58; Cl, 34.08; N, 4.49; O, 10.25; Te, 40.89

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AS-101; IVX-Q-101; PRX-0001; PRX-0002; PRX-001; WAX-120337; IVXQ-101; AS101; IVXQ101; PRX0001; PRX0002; PRX001;WAX120337; AS 101; IVX Q 101; PRX 0001; PRX 0002; PRX 001; WAX 120337; IVXQ 101;

IUPAC/Chemical Name: Ammonium trichloro(dioxoethylene-O,O') tellurate

InChi Key: AXWLPMGUUAIGJK-UHFFFAOYSA-O

InChi Code: InChI=1S/C2H4Cl3O2Te.H3N/c3-8(4,5)6-1-2-7-8;/h1-2H2;1H3/q-1;/p+1

SMILES Code: Cl[Te-]1(Cl)(Cl)OCCO1.[NH4+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:         

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 312.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Indenbaum V, Bin H, Makarovsky D, Weil M, Shulman LM, Albeck M, Sredni B, Mendelson E. In vitro and in vivo activity of AS101 against West Nile virus (WNV). Virus Res. 2012 Mar 14. [Epub ahead of print] PubMed PMID: 22445690.

2: Brodsky M, Halpert G, Albeck M, Sredni B. The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFkappaB signaling pathway and nitric oxide induction in macrophages. J Inflamm (Lond). 2010 Jan 20;7(1):3. PubMed PMID: 20205748; PubMed Central PMCID: PMC2822756.

3: Brodsky M, Hirsh S, Albeck M, Sredni B. Resolution of inflammation-related apoptotic processes by the synthetic tellurium compound, AS101 following liver injury. J Hepatol. 2009 Sep;51(3):491-503. Epub 2009 Jun 6. PubMed PMID: 19595469.

4: Daniel-Hoffmann M, Albeck M, Sredni B, Nitzan Y. A potential antimicrobial treatment against ESBL-producing Klebsiella pneumoniae using the tellurium compound AS101. Arch Microbiol. 2009 Aug;191(8):631-8. Epub 2009 Jun 16. PubMed PMID: 19529918.

5: Hayun M, Saida H, Albeck M, Peled A, Haran-Ghera N, Sredni B. Induction therapy in a multiple myeloma mouse model using a combination of AS101 and melphalan, and the activity of AS101 in a tumor microenvironment model. Exp Hematol. 2009 May;37(5):593-603. PubMed PMID: 19375650.

6: Sinuani I, Weissgarten J, Beberashvili I, Rapoport MJ, Sandbank J, Feldman L, Albeck M, Averbukh Z, Sredni B. The cyclin kinase inhibitor p57kip2 regulates TGF-beta-induced compensatory tubular hypertrophy: effect of the immunomodulator AS101. Nephrol Dial Transplant. 2009 Aug;24(8):2328-38. Epub 2009 Mar 25. PubMed PMID: 19321762.

7: Carmely A, Meirow D, Peretz A, Albeck M, Bartoov B, Sredni B. Protective effect of the immunomodulator AS101 against cyclophosphamide-induced testicular damage in mice. Hum Reprod. 2009 Jun;24(6):1322-9. Epub 2009 Feb 24. PubMed PMID: 19240057.

8: Friedman M, Bayer I, Letko I, Duvdevani R, Zavaro-Levy O, Ron B, Albeck M, Sredni B. Topical treatment for human papillomavirus-associated genital warts in humans with the novel tellurium immunomodulator AS101: assessment of its safety and efficacy. Br J Dermatol. 2009 Feb;160(2):403-8. Epub 2008 Sep 19. PubMed PMID: 18808418.

9: Sredni-Kenigsbuch D, Shohat M, Shohat B, Ben-Amitai D, Chan CC, David M. The novel tellurium immunomodulator AS101 inhibits interleukin-10 production and p38 MAPK expression in atopic dermatitis. J Dermatol Sci. 2008 Jun;50(3):232-5. Epub 2008 Jan 31. PubMed PMID: 18242062.

10: Frei GM, Kremer M, Hanschmann KM, Krause S, Albeck M, Sredni B, Schnierle BS. Antitumour effects in mycosis fungoides of the immunomodulatory, tellurium-based compound, AS101. Br J Dermatol. 2008 Mar;158(3):578-86. Epub 2008 Jan 30. PubMed PMID: 18241275.