K122

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 122391

CAS#: N/A

Description: K122 is an antibacterial agent and is an AMP Feleucin-K3 analogue modified with unnatural peptidomimetic sulfono-γ-AA building block. K122 exhibited potent and broadspectrum antimicrobial activity and high selectivity. K122 had a rapid bactericidal effect and a low tendency to induce resistance. Surprisingly, K122 showed excellent effectiveness against bacterial pneumonia. For biofilm and local skin infections, K122 significantly decreased the bacterial load and improved tissue injury at a dose of only 0.25 mg/kg, which was 160 times lower than the concentration deemed to be safe for local dermal applications.


Chemical Structure

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K122
CAS# N/A

Theoretical Analysis

MedKoo Cat#: 122391
Name: K122
CAS#: N/A
Chemical Formula: C57H105N13O10S
Exact Mass: 1,163.78
Molecular Weight: 1,164.610
Elemental Analysis: C, 58.79; H, 9.09; N, 15.64; O, 13.74; S, 2.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: K122; K 122; K-122

IUPAC/Chemical Name: (S)-6-amino-N-((S)-6-amino-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxohexan-2-yl)-2-((2S,5S,8S,14S)-14-amino-8-(4-aminobutyl)-2,5-diisobutyl-16-methyl-4,7,10-trioxo-12-tosyl-3,6,9,12-tetraazaheptadecanamido)hexanamide

InChi Key: ILUMOZYAPGCWPJ-ULCGJULCSA-N

InChi Code: InChI=1S/C57H105N13O10S/c1-35(2)28-41(61)33-70(81(79,80)42-23-21-40(11)22-24-42)34-50(71)63-43(18-12-15-25-58)52(73)67-49(32-39(9)10)57(78)69-47(30-37(5)6)55(76)65-44(19-13-16-26-59)53(74)64-45(20-14-17-27-60)54(75)68-48(31-38(7)8)56(77)66-46(51(62)72)29-36(3)4/h21-24,35-39,41,43-49H,12-20,25-34,58-61H2,1-11H3,(H2,62,72)(H,63,71)(H,64,74)(H,65,76)(H,66,77)(H,67,73)(H,68,75)(H,69,78)/t41-,43-,44-,45-,46-,47-,48-,49-/m0/s1

SMILES Code: CC(C)C[C@@H](CN(S(=O)(C1=CC=C(C)C=C1)=O)CC(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)N

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,164.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yang G, Yuan Y, Yuan H, Wang J, Yun H, Geng Y, Zhao M, Li L, Weng Y, Liu Z,
Feng J, Bu Y, Liu L, Wang B, Zhang X. Histone acetyltransferase 1 is a
succinyltransferase for histones and non-histones and promotes tumorigenesis.
EMBO Rep. 2021 Feb 3;22(2):e50967. doi: 10.15252/embr.202050967. Epub 2020 Dec
29. PMID: 33372411; PMCID: PMC7857430.

2: Banks CJ, Rodriguez NW, Gashler KR, Pandya RR, Mortenson JB, Whited MD,
Soderblom EJ, Thompson JW, Moseley MA, Reddi AR, Tessem JS, Torres MP, Bikman
BT, Andersen JL. Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs
SOD1-Mediated Inhibition of Mitochondrial Respiration. Mol Cell Biol. 2017 Sep
26;37(20):e00354-17. doi: 10.1128/MCB.00354-17. PMID: 28739857; PMCID:
PMC5615182.

3: Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz
K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGFβ2-induced epithelial to
mesenchymal transition of lens epithelial cells: selective acetylation of K56
and K122 in histone H3. Biochem J. 2020 Jan 17;477(1):75-97. doi:
10.1042/BCJ20190540. PMID: 31815277; PMCID: PMC8259308.